Egis Gyogyszergyar

Eva Poczik

Pal Benko

Attila Mandi

Frigyes Gorgenyi

Kalman Nagy

Daniel Bozsing

Peter Tompe

Istvan Simonyi

Ivan Beck

Laszlo Levai

Janos Imre

Eva Furdyga

Eva J Tajthy Nee Juhasz

Erzsebet Kiss Nee Bertok

Gyorgyi Kovanyi Nee Lax

Gyorgy Mikite

Gyorgyi Zalavari Nee Dosa

Ilona Dinnyes Nee Nagy

The invention relates to a process for the preparation of dimethyl-1,4-dihydro-2,6-dimethyl-4-(2'-nitro-phenyl)-pyridine-3,5-dicarbo xylate of the Formula I ##STR1## which comprises a) reacting a compound of the general Formula II ##STR2## (wherein n is 1 or 3; if n is 1, then R stands for a group of the Formula (a) ##STR3## and if n is 3, then R represents hydrogen) with methyl acetoacetate of the Formula III

1,4,Dihydro-pyridine intermediates

The invention is directed to processes for the preparation of dimethyl-1,4-dihydro-2,6-dimethyl-4-(2'-nitrophenyl)-pyridine-3,5-dicarbox ylate by reacting 1-methoxy-1-(2'-nitrophenyl)-N-(2'-nitrophenyl)methylene methanamie or 1-(2'-nitrophenyl)-N,N'-bis-(2'-nitrophenyl) methylene methanediamine with methyl acetoacetate in the presence of an amine compound or by reacting the monomeric or trimeric from of 2-nitrobenzaldimine with methyl acetoacetate.

Process for the preparation of 1,4-dihydro-pyridine derivatives

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Budapest, Hungary

Eva Poczik