Spofa Spojene Podniky Pro Zdravotnickou

Vyzkumng, Ustav Pro Farmacii a Biochemii, Statni Podnik

Spojene Podniky Prozdravotnickou Vyrobu (spofa)

Eva Maturova

Jaroslava Grimova

Bohumila Brunova

Miroslav Kuchar

Ludmila Fisnerova

Marie Poppova

This relates to substances represented by formula (I), wherein X stands for represented by either OR in which R is an alkyl of 1 to 4 carbon atoms, or NHR in which is an alkyl of 1 to 4 carbon atoms, or a (CH.sub.2).sub.n NR.sub.2 group wherein n is 2 or 3 while R.sup. is an methyl or an ethyl group; eventually X may represent morpholinyl. Also considered are salts of 4-(2,4-difluorbiphenylyl)-2-methyl-4-oxobutanoic acid with appropriate inorganic or organic bases represented by formula (II) wherein B.sup.+ is either an alkaline metal cation, alkaline earth metal cation, cyclohexylamine cation, or lysine cation. Said substances are characterized by antiinflamatory properties comparable to (and greater than) the initial acid while simultaneously said modifications of their physico-chemical properties broaden the posibilities of their therapeutic application. ##STR1##

Derivatives of 4-(2,4-difluorbiphenylyl)-2-methyl-4-oxobutanoic acid

An etheric derivative of 4(3H)-quinazolinone which is a fluorinated 3-[2-(4-biphenylyloxy)ethyl]-4(3H)-quinazolinone, produced by reacting said 4(3H)-quinazolinone with the corresponding fluorinated 4-(2-chloroethoxy)biphenyl, and its acid addition salts, especially the hydrochloride. This compound possesses substantially higher analgesic activity and lower acute toxicity than aminophenazone, ibuprofen, acetylosalicyclic acid and paracetamol.

Etheric derivative of 4(3H)-quinazolinone and a process for preparation

The invention relates to omega-(2',4'-dihalobiphenylyl)oxo alkanoic acids of Formula: ##STR1## wherein X.sup.1 and X.sup.2 each represent a fluorine or chlorine atom and Y represents a bivalent hydrocarbon chain selected from the group consisting of --CH.sub.2 --CH--CH.sub.3 and (CH.sub.2).sub.3, and to a process for their preparation. The compounds of the invention are highly active and longlasting anti-inflammatory agents.

Omega-(2,4-dihalobiphenylyl) oxo alkanoic acids

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Zvonkova, Czechoslovakia

Eva Maturova