Hoffmann-la Roche Inc.

Eva-Maria Gutknecht

Albert E Fischli

Daniel Obrecht

Werner Neidhart

Henri Ramuz

Wolfgang Wostl

Georges Hirth

Thierry Godel

Quirico Branca

Jean-Marie Cassal

Albrecht Edenhofer

Hans Lengsfeld

Nigel Gains

Compounds of the formula: ##STR1## wherein R.sup.1 and R.sup.2 each individually are hydrogen or lower alkyl optionally substituted by aryl or C.sub.3-6 -cycloalkyl;

Octahydrophenanthrene derivatives

Compounds which are amino acid derivatives and have the formula ##STR1## in which R.sup.1 is hydrogen or methyl, R.sup.2 is ethyl, propyl or imidazol-4-yl, R.sup.3 is isobutyl, cyclohexylmethyl or benzyl, and A is defined as herein are useful as renin inhibitors.

Renin inhibiting compounds

Steroids of the formula ##STR1## wherein R.sup.1 to R.sup.4, X and n have the significance given in the description, which lower the intestinal resorption of cholesterol and plasma cholesterol and a process of making same from corresponding steroids having an alcohol residue of the formula --O--X--OH in the 3-position.

Steroids

Propiolophenone derivatives of the formula ##STR1## wherein R.sup.6 is hydrogen, lower alkyl or a group of the formula ##STR2## as well as corresponding hydroxy compounds of the formula ##STR3## wherein R.sup.6' is hydrogen, lower alkyl, a group of formula (a), (b), (c), (d) or (e) or a group of the formula

Propiolophenone derivatives

Styryl ketones of the formula ##STR1## wherein R.sup.8 and R.sup.9 are independently hydrogen or lower alkyl or together represent an additional carbon-carbon bond and

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Buggingen-Seefelden, Germany

Eva-Maria Gutknecht