Kabi Pharmacia Ab

Eva Maria Gray (Hellstrom)

Jack Spira

Mona Sydow-Backman

Helena Inga Sandberg

Catherine Ljung

Helena Wiman

Peter Lind

Annelie B Almstedt

A DNA sequence coding for a biologically active recombinant human factor VIII derivative, comprising a first DNA segment coding for the amino acids 1 through 740 of human factor VIII and a second DNA segment coding for the amino acids 1649 through 2332 of human factor VIII, said segments being interconnected by a linker DNA segment coding for a linker peptide of at least 3 amino acid residues and up to about 10 amino acid residues which are selected from lysine and arginine; recombinant expression vector comprising such DNA sequence; host cells of animal origin transformed with such recombinant expression vector; a process for the manufacture of recombinant human factor VIII derivative; and human factor VIII derivative containing the heavy chain and the light chain linked by metal ion bond.

Recombinant human factor VIII derivatives

Growing community of inventors

Stockholm, Sweden

Eva Maria Gray (Hellstrom)