Alligator Bioscience Ab

Eva Maria Dahlén

Björn Walse

Patrick Thomas Höjman

Marie Asa Ingegerd Karlsson

Mats Peter Anderson

Cecilia Ann-Christin Malmborg Hager

Karin Elisabeth Barchan

Cecilia Ann-Christin Malmborg Hanger

Karin Elisabeth Brachan

The invention provides an isolated polypeptide comprising a variant amino acid sequence of SEQ ID NO: 1, or a fusion or derivative of said polypeptide, or a fusion of a said derivative thereof, wherein the polypeptide, fusion or derivative retains a biological activity of wild type IL-IRa. In one embodiment, the isolated polypeptide, fusion or derivative is or comprises a polypeptide variant of amino acid sequence SEQ ID NO: 1 comprising or consisting of substitutions at one or more of the following amino acid mutations of SEQ ID NO: 1: Q29K, P38Y, P38R, L42W, D47N, E52R, H54R, E90Y, Q129L, Q129N, M136N, M136D and Q149K. Also provided are pharmaceutical compositions of the above polypeptide, fusion or derivative, as well as uses of the same for treating a disease or condition capable of being treated by an agent which inhibits the function of IL-1 receptors.

Mutants of interleukin-1 receptor antagonist

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Arlöv, Sweden

Eva Maria Dahlén