Astra Aktiebolag

Eva M Persson

Uli A Hacksell

Sven-Erik Hillver

Hong Yu

Anna L Bjork

Karl J Vallgangrda

Nils-Erik Anden

Ye Liu

Berit C Backlund Hook

Eva C Mellin

A compound of the formula ##STR1## Z is hydrogen or halogen, Q is COR.sup.1 or 5-or 6-membered aryl which may contain 1 or 2 heteroatoms selected from N, 0 or S and may be substituted or fused wherein R is hydrogen or C.sub.1 -methyl (cis-configuration), R.sup.1 is C.sub.1 -C.sub.6 alkyl or an aromatic ring which may contain heteroatoms selected from O and S and may be substituted or fused to an optionally substituted benzene ring, R.sup.2 is hydrogen or C.sub.1 -C.sub.6 alkyl and R.sup.3 may be different groups defined in claim 1, and enantiomers/salts thereof, processes for preparation of said compounds, pharmaceutical preparations containing said compounds, use of and method of treatment of disorders in CNS by using said compounds.

8-substituted-2-aminotetralins

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Uppsala, Sweden

Eva M Persson