University of California

Fox Chase Cancer Center

Immunomedics, Inc.

Eva M Horak

David M Goldenberg

Hans J Hansen

Chien-Hsing Chang

James David Marks

Louis M Weiner

Gregory P Adams

Edmund A Rossi

Zhengxing Qu

Jeng-Dar Yang

Chien Hsing Chang

Ivan David Horak

Chien-Hsing Ken Chang

Bispecific single chain antibody molecules are disclosed which may be used to advantage to treat various forms of cancer associated with the overexpression of members of the EGFR protein family.

Bispecific single chain Fv antibody molecules and methods of use therof

Anti-EGFR family member antibodies and bispecific antibodies comprising one or more anti-EGFR family member antibodies are disclosed. These antibodies can be used to advantage to specifically target forms of cancer associated with the overexpression of members of the EGFR protein family.

Anti-EGFR family antibodies, bispecific anti-EGFR family antibodies and methods of use thereof

Bispecific single chain Fv antibody molecules and methods of use thereof

Disclosed herein are compositions and methods for increasing the longevity of a cell culture and permitting the increased production of proteins, preferably recombinant proteins, such as antibodies, peptides, enzymes, growth factors, interleukins, interferons, hormones, and vaccines. By transfecting cells in culture with an apoptosis-inhibiting gene or vector, cells in culture can survive longer, resulting in extension of the state and yield of protein biosynthesis. Expression of the apoptosis-inhibitor within the cells, because it does not kill the cells, allows the cells, or an increased fraction thereof, to be maintained in culture for longer periods. This invention then allows for controlled, enhanced protein production of cell lines for commercial and research uses, particularly the enhanced production of growth factors, interferons, interleukins, hormones, enzymes, and monoclonal antibodies, and the like. The method preferentially involves eukaryotic cells in culture, and more advantageously mammalian cells in culture.

Methods and compositions for increasing longevity and protein yield from a cell culture

Growing community of inventors

West Orange, NJ, United States of America

Eva M Horak