Institute for Drug Research Ltd.

Richter Gedeon Vegyeszeti Gyar Rt

Biogal Gyogyszergyar Rt.

Richer Gedeon Vegyeszet

Eva Ilkoy

Gabor Ambrus

Istvan M Szabo

Gyula Horvath

Antonia Jekkel

Imre Moravcsik

Attila Andor

Karoly Albrecht

Istvan Barta

Ildiko Lang

Gyorgy Somogyi

Julianna Mozes Nee Suto

Margit Bidlo Nee Igloy

Sandor Boros

Attila Konya

Janso Salat

Kalman Konczol

Laszlo Birincsik

Laszlo Szporny

Gyorgy Hajos

Tibor Lang

Janos Erdei

Andrea Maderspach

Laszlo Cseke

Istvan Pallagi

Gyorgy Santha

Ferenc Szederkenyi

Antonia Jekkel Nee Bokany

Kalman Polya

Mihaly Kaszas

Nandor Makk

Emilia Simonovits

Andras Javor

Lajos Kiss

Karoly Nagy

Jozsef Nagy

Ilona Varga

Gabor Hantos

Antalne Jekkel

Andras Toro

Andras Kiss

Istvan Magyi

Edit Halasz

Zsuzsanna Lengyel Nee Szemenyei

Eva Csajagi

Laszlo Birinesik

Zsuzesanna Vida

Janos Salat

Microbial process for preparing pravastatin

The invention refers to a new microbial process for preparing .beta.,.delta.-dihydroxy-7-[1,2,6,7,8,8a-hexahydro-2.6-dimethyl-8-(2-methy l-butyryloxy)-naphthalen-1-yl]-heptanoic acid .delta.-lactone of formula (I) and .beta.,.delta.-dihydroxy-7-[1,2,6,7,8,8a-hexahydro-2.6-dimethyl-8-(2-methy lbutyryloxy)-naphtalen-1-yl]-heptanoic acid of formula (II), ##STR1## by the aerobic fermentation of the submerged culture of an imperfect fungus strain biosynthesizing the above compounds, in a nutrient medium containing utilizable carbon and nitrogen sources as well as mineral salts, and by isolating the product of formula (I), which comprises cultivating a strain of the new Aspergillus obscurus fungus species producing the above compound(s) of formulas (I) and/or (II), in a temperature range of 25.degree. to 30.degree. C. and, if desired, separating the product(s) formed from the fermentation broth, then isolating it in the lactone form of formula (I) and, if desired, purifying the same.

Microbial process for preparing mevinolin by a strain of aspergillus

The invention relates to a novel process for the preparation of 17 .alpha.-hydroxy-20-oxopregnane derivatives of the general formula (I), ##STR1## wherein R.sub.1 means a hydroxy or an oxo group; and

Process for the preparation of steroids bearing

9.alpha.-hydroxy-3-oxo-4,24(25)-stigmastadien-26-oic acid derivatives, a

The invention relates to a process for the production of 9.alpha.-hydroxy-4-androstene-3,17-dione from natural sterols of plant or animal origin or from mixtures thereof by the submerged aerobic fermentation of an enzyme-deficient, sterol-de-grading microorganism in a nutrient medium containing utilizable carbon and nitrogen sources as well as mineral salts, and by isolating the product formed, which comprises transforming the sterol or sterol mixture with the culture of a 1,2-steroid-dehydrogenase deficient strain of new Mycobacterium roseum species which is able to degrade the side-chain of natural sterols, preferably with Mycobacterium roseum sp. nov. 1108/1 deposited at the National Collection of Agricultural and Industrial Microorganisms, Budapest, Hungary under the number NCAIM B (P) 000339, and by isolating and purifying the 9.alpha.-hydroxy-4-androstene-3,17-dione obtained.

Microbiological process for preparing

Growing community of inventors

Budapest, Hungary

Eva Ilkoy