Roche Diagnostics Gmbh

Eva H&ouml;ss

Christoph Seidel

Ursula-Henrike Wienhues

Elke Faatz

Michael Wiedmann

Beatus Ofenloch-H&auml;hnle

Cornelia Kruse-M&uuml;ller

The invention concerns a process for the production of metal chelate-labelled peptide antigens, peptides obtainable by this process and their use in an immunological method of detection.

Metal chelate-labelled peptides

The invention concerns a method for the immunological determination of a specific antibody in a sample liquid in which the sample liquid is incubated in the presence of a solid phase with two antigens directed against the antibody to be determined of which the first antigen carries at least one marker group and the second antigen is (a) bound to the solid phase or (b) is present in a form capable of binding to the solid phase and the antibody to be determined is detected by determining the marker group in the solid phase or/and in the liquid phase characterized in that at least one of the two antigens contains several epitope regions which react with the antibody to be determined.

Determination of a specific immunoglobulin using multiple antigens

Metal chelate-labelled peptide which has a maximum length of 50 amino acids and is coupled to at least one luminescent metal chelate at the amino terminus or/and at amino side groups, wherein the at least one luminescent metal chelate is present on the peptide at a predetermined position on the peptide.

Growing community of inventors

Starnberg, Germany

Eva Höss

Growing community of inventors

Starnberg, Germany

Eva H&ouml;ss

Eva Höss