Egis Gyogyszergyar

Egis Gyogyszergyar Rt.

Eva Furdyga

Attila Mandi

Kalman Nagy

Tibor Mezei

Zoltan Budai

Pal Benko

Frigyes Gorgenyi

Daniel Bozsing

Klara Reiter Nee Esses

Peter Tompe

Ivan Beck

Istvan Simonyi

Laszlo Levai

Janos Imre

Eva J Tajthy Nee Juhasz

Gyorgyi Kovanyi Nee Lax

Gyorgy Mikite

Gyorgyi Zalavari Nee Dosa

Eva Poczik

Ilona Dinnyes Nee Nagy

Erzsebet Kiss Nee Bertok

Gyula Simig

Lujza E Petocz

Gabor Gigler

Istvan Gacsalyi

Gabor Blasko

Eniko Szirt Nee Kiszelly

Aranka Lay Nee Konya

Imre Klebovich

Maria Szecsey Nee Hegedus

Margit Csorgo

Ilona Sztruhar

Judit Szego

Istvan Gertyan

Gyongyi Vereczkey Nee Donath

Laszlo Koncz

Process for the preparation of 8 -[4 -[4-(pyrimidine-2-yl)-piperazine-1-yl]-butyl]-8-aza-spiro[4.5]decane-7,9-d ione (buspiron) of the Formula I ##STR1## and the hydrochlorides thereof having high purity by continuously adding a solution of 8-[4-[4-(pyrimidine-2-yl)-piperazine-1-yl]-but-2 -inyl]-8-aza-spiro[4.5]decane-7,9-dione of the formula II ##STR2## formed with an inert organic solvent having a concentration of at least 40% by weight to a suspension of a hydrogenation catalyst in an inert organic solvent and optionally converting the 8-[4-[4-(pyrimidine-2-yl)-piperazine-1-yl]-butyl]-8-aza-spiro[4.5]decane-7 ,9-dione thus obtained into the hydrochloride thereof.

Process for the preparation of high purity buspiron and the

The invention relates to a process for the preparation of dimethyl-1,4-dihydro-2,6-dimethyl-4-(2'-nitro-phenyl)-pyridine-3,5-dicarbo xylate of the Formula I ##STR1## which comprises a) reacting a compound of the general Formula II ##STR2## (wherein n is 1 or 3; if n is 1, then R stands for a group of the Formula (a) ##STR3## and if n is 3, then R represents hydrogen) with methyl acetoacetate of the Formula III

1,4,Dihydro-pyridine intermediates

The invention is directed to processes for the preparation of dimethyl-1,4-dihydro-2,6-dimethyl-4-(2'-nitrophenyl)-pyridine-3,5-dicarbox ylate by reacting 1-methoxy-1-(2'-nitrophenyl)-N-(2'-nitrophenyl)methylene methanamie or 1-(2'-nitrophenyl)-N,N'-bis-(2'-nitrophenyl) methylene methanediamine with methyl acetoacetate in the presence of an amine compound or by reacting the monomeric or trimeric from of 2-nitrobenzaldimine with methyl acetoacetate.

Process for the preparation of 1,4-dihydro-pyridine derivatives

The new compounds of the general Formula I ##STR1## (wherein A stands for a C.sub.2-4 straight or branched chain alkylene group;

Substituted styrene derivatives

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Budapest, Hungary

Eva Furdyga