Masarykova Univerzita

Eva Chovancova

Jiri Damborsky

Zbynek Prokop

Jan Brezovsky

Veronika Stepankova

Radka Chaloupkova

Tana Koudelakova

Artur Wiktor Gora

Thermostabilization of a protein where the protein contains access routes and wherein at least one amino acid in the bottleneck of the access route is mutated, includes identifying the amino acids of the bottleneck and the amino acids control exchange of the solvent between a buried protein core and surrounding environment and/or in the packing of the amino acids inside the access route. Modification of the amino acids are determined so that the packing of the amino acids inside the tunnel is improved and the access route prevents access of undesired solvent molecules to the protein core, while allowing passage of the compounds necessary at the protein core to enable the protein to perform its biological function.

Method of thermostabilization of a protein and/or stabilization towards organic solvents

Growing community of inventors

Tisnov, Czechia

Eva Chovancova