Tibotec Pharmaceuticals Ltd.

Tibotec Bvba

Eva Bettens

Jan Heeres

Abdellah Tahri

Kurt Hertogs

Lucien Maria Henricus Koymans

Jerôme Emile Georges Guillemont

Paulus Joannes Lewi

Frederik Frans Desiré Daeyaert

Hendrik Maarten Vinkers

Elisabeth Thérese Jeanne Pasquier

Bart Rudolf Romanie Kesteleyn

Wim Van De Vreken

Natalie Maria Francisca Kindermans

Maxime Francis Jean-Marie Ghislain Canard

Veronique Corine Paul De Vroey

Dirk Edward Désiré Jochmans

Frank Xavier Jozef Herwig Arts

Frank Xavier Jozef Herwig, Legal Representative

Jerome Emile Guillemont

Elisabeth Therese Pasquier

Paul Adriaan Janssen

Paul Adrian Janssen

Jing Wang

The present invention concerns the compounds of formula (I) their N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites, wherein n is 1, 2 or 3; Ris H, CN, halo, aminoC(&#x2550;O), C(&#x2550;O)OH, CalkyloxyC(&#x2550;O), CalkylC(&#x2550;O), mono- or di(Calkyl)aminoC(&#x2550;O), arylaminoC(&#x2550;O), N-(aryl)-N&#x2014;(Calkyl)aminoC(&#x2550;O), methanimidamidyl, N-hydroxy-methanimidamidyl, mono- or di(Calkyl)methanimidamidyl, Hetor Het; Ris H, Calkyl, Calkenyl, Ccycloalkyl, wherein said Calkyl, Calkenyl and Ccycloalkyl may be optionally substituted; Ris nitro, cyano, amino, halo, hydroxy, Calkyloxy, hydroxyC(&#x2550;O), aminoC(&#x2550;O), CalkyloxyC(&#x2550;O), mono- or di(Calkyl)aminoC(&#x2550;O), CalkylC(&#x2550;O), methanimidamidyl, mono- or di(Calkyl)methanimidamidyl, N-hydroxy-methanimidamidyl or Het; for use as a medicine. The invention further relates to a novel subgroup of the compounds of formula (I), and to compositions comprising compounds of formula (I).

Substituted indolepyridinium as anti-infective compounds

This invention concerns HIV replication inhibitors of formula (I), the N-oxides, the pharmaceutically acceptable addition salts, the quaternary amines and the stereochemically isomeric forms thereof, their use as a medicine, their processes for preparation and pharmaceutical compositions comprising them.

HIV replication inhibiting pyrimidines and triazines

This invention concerns HIV replication inhibitors of formula (I), The N-oxides, the pharmaceutically acceptable addition salts, the quaternary amines and the stereochemically isomeric forms thereof, their use as a medicine, their processes for preparation and pharmaceutical compositions comprising them. 

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Zoersel, Belgium

Eva Bettens