Caprion Proteomics Inc.

Case Western Reserve University

Albert Einstein College of Medicine

Val-chum, Limited Partnership

Adaerata, Limited Partnership

Idexx Corporation

Caption Biosciences Inc.

Caprion Biosciences Inc.

Caprion Pharmaceuticals, Inc.

Eustache Paramithiotis

Pascal Croteau

Neil Cashman

Marc Pinard

Robert L Lawton

Jacqueline Michele Achkar

W Henry Boom

Marc Prentki

Lisa Ann Estey

Ashkan Haghighat

Trebor Lawton

Charles Bark

Joel Lanoix

Jacek Slon-Usakiewicz

Sr Murthy Madiraju

Sylvie La Boissière

Rèmi Rabasa-Lhoret

Èrik Joly

Susan Francoeur, Legal Representative

The present invention provides biomarkers, methods and kits for diagnosing latent tuberculosis (TB) in a subject exposed to TB, and methods and kits for monitoring the effectiveness of treatment for latent TB.

Biomarkers of latent tuberculosis infection

The present invention provides biomarkers, methods and kits for diagnosing and prognosing the development of impaired glucose tolerance in a subject and the progression of diabetes in a subject, as well as methods for identifying a compound that can inhibit the development of impaired glucose tolerance and/or type 2 diabetes; reduce or slow down the progression of normal glucose tolerance to impaired fasting glycaemia, to impaired glucose tolerance, and/or to diabetes; and/or reduce or inhibit the development of complications associated with the disease in a subject, and methods for inhibiting the development of impaired glucose tolerance and/or type 2 diabetes; reducing or slowing down the progression of normal glucose tolerance to impaired fasting glycaemia, to impaired glucose tolerance, and/or to diabetes; and/or reducing or inhibiting the development of complications associated with the disease in a subject.

Type 2 diabetes biomarkers and uses thereof

The present invention provides biomarkers, methods and kits for diagnosing a Brucellosis, Q-Fever, and/or Lyme Disease, methods and kits for monitoring the effectiveness of treatment for Brucellosis, Q-Fever, or Lyme Disease, as well as methods for identifying a compound that can treat Brucellosis, Q-Fever, and/or Lyme Disease reduce or inhibit the development of complications associated with the disease in a subject, and methods to treat a Brucellosis, Q-Fever, and/or Lyme Disease.

Brucellosis, Q-fever, and lyme disease biomarkers and uses thereof

The present invention provides biomarkers, methods and kits for diagnosing active tuberculosis in a subject, methods and kits for monitoring the effectiveness of treatment for active TB, as well as methods for identifying a compound that can treat TB reduce or inhibit the development of complications associated with the disease in a subject, and methods to treat active TB.

Tuberculosis biomarkers and uses thereof

The present invention features methods for identifying peptides that selectively bind to PrPor fragments thereof. The invention also features the use of such peptides in screening methods for the identification of candidate agents useful for the treatment of a prion disease.

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In general, the invention features antibodies specific for PrPand diagnostic, therapeutic, and decontamination uses thereof. The invention also features synthetic peptides useful as immunogens for generating antibodies specific for PrPand therapeutic for the treatment of prion diseases.

Antibodies to a YYX epitope of a mammalian prion protein

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Boucherville, Canada

Eustache Paramithiotis