Seoul National University

Lg Innotek Co., Ltd.

Korea Research Institute of Bioscience and Biotechnology

Eunmi Kim

Jung Weon Lee

Se Mi Kim

Seo Hee Nam

Eun Ae Shin

Junghwa Yoon

Dongjoon Ko

The present disclosure relates to TM4SF5-specific humanized antibodies and uses thereof.

TM4SF5-targeting humanized antibody and use thereof

The present invention relates to an immunosuppressant comprising TSAHC or a pharmaceutically acceptable salt thereof as an active ingredient. TSAHC treatment suppressed the expression and secretion of cytokines/chemokines such as IL6, IL1β, TNFα, CXCL1, CXCL2, CXCL3, CXCL6, CXCL8, CCL2, CCL5, CCL20, CXCL10 and CCR10 according to the expression of TM4SF5 gene and protein, and the cytokines or chemokines mediated by the expression of TM4SF5 induced abnormalities in the inflammatory response and metabolic function of liver tissues, hepatic epithelial cells and macrophages, and correlated with liver tissue damage and immune cell recruit in TM4SF5 transgenic animals. Therefore, a composition comprising TSAHC or a pharmaceutically acceptable salt thereof as an active ingredient can be effectively used as an immunosuppressant.

Immunosuppressant comprising TSAHC or a pharmaceutically acceptable salts thereof as an active ingredient

The present invention relates to a camera module, the module including a case embedded with a lens, a base supporting the case and formed with a window for passing an optical image emitted by the lens, the window being formed with a staircase unit, and a PCB (Printed Circuit Board) mounted with the base and an image sensor for converting the optical image to an electrical signal.

Camera module having structure to reduce flare phenomenon

Growing community of inventors

Seoul, South Korea

Eunmi Kim