Daegu-gyeongbuk Medical Innovation Foundation

National Cancer Center

Samsung Life Public Welfare Foundation

Pimedbio, Inc.

Eunmi Hong

Hwan Geun Choi

So Young Kim

Jung Beom Son

Nam Doo Kim

Yi Kyung Ko

Seock Yong Kang

Eunhwa Ko

Sun-Hwa Lee

Seungyeon Lee

Jin-Hee Park

Sun Joo Lee

Dayea Kim

Jae Hyun Bae

Sang Bum Kim

Seung Hoon Lee

Do-Hyun Nam

Jong Bae Park

Suk Kyoon Yoon

Hee Yoon Ryu

Heejin Lee

Joong-heui Cho

Sang Hyun Min

Jun Woo Kim

Doohyun Lee

Sangbum Kim

Tae-Ho Jang

Dong Kyu Choi

Sungwoo Lee

Seongho Hong

Younho Lee

Hyunkyoung Kim

Joongheui Cho

Shinae Kim

Tae-ho Jang

Jaeyoung Song

Yunho Lee

Bae Jun Oh

Hui-Jeon Jeon

Young-Hoon Park

Ji Hoon Yu

Jeong-Eun Park

Nam Hui Kim

Chang Hoon Seo

Minsoo Song

Eun Bi Ko

Chun Young Im

Ga Young Park

The present invention relates to a novel pyrrolo-pyrimidine derivative compound, a preparation method therefor, and a pharmaceutical composition comprising the same compound as an effective ingredient for preventing or treating a protein kinase-related disease. The compound represented by Chemical Formula 1 according to the present invention, an optical isomer thereof, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same as an effective ingredient has outstanding inhibitory activity against LRRK2 kinase and against phosphorylation in the NIH-3T3 cell line, which is an LRRK2-expressing cell line, and NCC01 and 448T cell lines, which are both derived from patients with brain tumors. Verified to have inhibitory activity against various protein kinases in addition to LRRK2, the compound can find effective applications in the treatment or prevention of protein kinase-related diseases. 

Pyrrolo-pyrimidine derivative compound, preparation method therefor, and pharmaceutical composition comprising same compound as effective ingredient for preventing or treating protein kinase-related disease

The present invention relates to a novel imidazopyridine derivative, a method for preparing the same, and a pharmaceutical composition containing the same as an active ingredient for preventing or treating cancer. The novel imidazopyridine derivative according to the present invention, a stereoisomer thereof and a pharmaceutically acceptable salt thereof can effectively inhibit cancer-related kinases, are excellent in inhibiting proliferation of cancer cells in a cancer cell line, and effectively inhibit proliferation of cancer cells (cancer cell apoptosis) in a cancer cell heterograft model, and thus can be useful as a pharmaceutical composition containing the same as an active ingredient for preventing or treating cancer. Also, the novel imidazopyridine derivative according to the present invention, the stereoisomer thereof, and the pharmaceutically acceptable salt thereof can effectively inhibit Src and Fyn, thereby being useful as a pharmaceutical composition for preventing or treating the Src and Fyn related diseases, and in particular, have been confirmed to be useful in diabetic nephropathy in animal model experiments. Therefore, the compound of the present invention can be effective as a pharmaceutical composition containing the same as an active ingredient for preventing or treating diabetic nephropathy.

Imidazopyridine derivative, method for preparing same, and pharmaceutical composition containing same as active ingredient for preventing or treating cancer

Growing community of inventors

Daegu, South Korea

Eunmi Hong