Yonsei University

Eunji Jang

Byunghoon Kang

Seungjoo Haam

Yong-min Huh

Hyun-Ouk Kim

Jihye Choi

Ilkoo Noh

Jaemoon Yang

Jin-Suck Suh

Seung Won Song

Seungmin Han

Seo Ryung Bae

Hwunjae Lee

Haejin Chun

A bioenvironment-sensitive nanoparticle including a polymer having complementary charges, a method of manufacturing the same, and a pharmaceutical use of the bioenvironment-sensitive nanoparticle are disclosed. The bioenvironment-sensitive nanoparticle can be useful in stably and effectively delivering a target material such as a drug even when used at a small quantity since the nanoparticle is stable in extracellular environments. Also, the bioenvironment-sensitive nanoparticle can be useful in selectively diagnosing or treating cancer cells since the nanoparticle is specific to environments of the cancer cells.

Bioenvironment-sensitive nanoparticle comprising polymer having complementary charges

The present invention relates to an amphiphilic nanoparticle specific to a biomarker, and more particularly, provides an amphiphilic nanoparticle which may be used as a diagnosis or treatment-type drug or gene carrier by selectively recognizing a proteolytic enzyme specifically expressed in a cellular membrane of a specific cell, and then being bound to the proteolytic enzyme to efficiently achieve the intracellular uptake and selective cleavage. The amphiphilic nanoparticle of the present invention may be used in the diagnosis or therapy of a disease.

Biomarker specific amphiphilic nanoparticles

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Seoul, South Korea

Eunji Jang