International Business Machines Corporation

Eunice Leong Jiayu

James L Hedrick

Dylan J Boday

Rudy J Wojtecki

Jeannette M Garcia

Yi Yan Yang

Willy Chin

Zhi Xiang Voo

Shrinivas Venkataraman

The present disclosure relates to polythioaminals with applications as carriers or delivery vehicles for therapeutic agents or other small molecule cargo. Polythioaminal block copolymer coupled to a therapeutic agent is a polymer-therapeutic conjugate that exhibits higher stability and longer life time in aqueous environments. The polythioaminal block copolymer coupled to a therapeutic agent can be synthesized by reacting hexahydrotriazines with a hydrophobic block precursor, a hydrophilic block precursor, a particle stabilizing segment precursor, and a cargo, such as a therapeutic agent, in a one pot synthesis. The ease of synthesizing the resulting polythioaminal block copolymer coupled to the therapeutic agent while offering the extended stability and polymer life time in aqueous environments make the polythioaminal block copolymer particularly attractive for therapeutic carriers.

Preparation of robust polythioaminal carriers

Growing community of inventors

Singapore, Singapore

Eunice Leong Jiayu