Lg Chem, Ltd

Korea Research Institute of Chemical Technology

The Industry & Academic Cooperation in Chungnam National University (iac)

Digmbio. Inc.

The Industry & Academic Cooperation in Chungnam National University

Eunhee Kim

Sung-Eun Yoo

Young Hee Lim

Sooyoung Kwak

Yu Ra Lee

Young-Hoon Kim

Jin-Woo Kim

Kyu Yang Yi

Choun-Ki Joo

Nam Sook Kang

Tae-Sung Koo

Changmin Park

Jeehee Suh

Younghoon Kim

Sehwan Oh

Ki-Hong Jang

Younggwan Kim

Ahram Shim

Jaehee Seol

Juhee Lee

Haeyoung Suh

Yun-Suk Lee

Nakjeong Kim

Yong-Sam Jung

Tae-Kyu In

Hyun-Ju Bae

Min-Young Park

The present invention relates to isoquinolinone derivatives, a method for preparing the same, and a pharmaceutical composition for preventing or treating poly(ADP-ribose) polymerase-1 (PARP-1)-related diseases containing the same as an active ingredient. The isoquinolinone derivatives exhibit an excellent PARP-1 inhibitory effect at a concentration of nanomolar units, and further exhibit an excellent cytoprotective effect (apoptosis inhibitory effect) on ophthalmic diseases or disorders, specifically retinal disorders, and thus can be effectively used as a pharmaceutical composition for preventing or treating PARP-1-related diseases, for example, ophthalmic diseases or disorders, which contains the same as an active ingredient.

Isoquinolinone derivatives, method for preparing the same, and pharmaceutical composition for preventing or treating poly(ADP-ribose) polymerase-1-related diseases, comprising the same as active ingredient

The present disclosure relates to a method for analysis of a deuterium substitution rate of a deuterium-substituted sample according to substitution positions using information of aH-NMR spectrum of the deuterium-substituted sample.

Method for determining the deuterium substitution rate according to substitution positions

The present disclosure relates to a method for analysis of an average deuterium substitution rate of a deuterium-substituted sample using information of aH-NMR spectrum of the deuterium-substituted sample.

Method for determining the average deuterium substitution rate

The present invention relates to a novel indene derivative, a preparation method for the same, and a pharmaceutical composition for treating retinal disease comprising the same as an active ingredient. The novel indene derivative of the present invention, the optional isomer of the same, or the pharmaceutically acceptable salts of the same have excellent inhibitory efficiency of receptor-interacting serine-threonine-protein kinase 1 (RIPK1). Therefore, the composition containing the same as an active ingredient can be effectively used as a pharmaceutical composition for treating retinal disease.

Fused heterocyclic ring compounds and method of treating retinal disease using same

Provided are aminopyrazole derivatives, a process for the preparation thereof, and a composition for preventing or treating an ischemic disease containing the same. Since the aminopyrazole derivatives of the present invention can reduce an ischemic cell death significantly, they can be effectively used for the prevention and treatment of ischemic diseases mediated by ischemic cell death, or protection of organs.

Aminopyrazole derivatives, process for the preparation thereof, and composition for preventing or treating ischemic diseases containing the same

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Daejeon, South Korea

Eunhee Kim