Korea Institute of Science and Technology

Korea Research Institute of Bioscience and Biotechnology

Eun-Sook Lee

Tae-Sook Jeong

Myung-Sook Choi

Song-Hae Bok

Surk-Sik Moon

Yong-Kook Kwon

Ki-Hwan Bae

Yong-Bok Park

Yang-Kyu Choi

Chul-Ho Lee

Byung-Hwa Hyun

Sae-Bom Lee

Young-Bae Park

Hyo-Soo Kim

Kwang-Hee Son

Byoung-Mog Kwon

Young-Kook Kim

Sung-Uk Kim

Ingyu Hwang

Doil Choi

Jung-Ah Ahn

Byung-Tae Ahn

Sung-Gyu Kim

Og-Sung Moon

Jun-Sung Lee

Seong-Choon Choe

0A method for treating or preventing an elevated blood lipid level-related disease in a mammal, which comprises administering thereto an effective amount of rutin, quercetin or a mixture thereof.

Method for preventing or treating elevated blood lipid level-related diseases by administering rutin and quercetin

A method for treating or preventing an elevated blood lipid level-related disease in a mammal, which comprises administering thereto an effective amount of rutin, quercetin or a mixture thereof.

A method for treating or preventing an elevated blood lipid level-related disease such as hyperlipidemia, arteriosclerosis, angina pectoris, stroke and hepatic diseases in a mammal, which comprises administering thereto an effective amount of a cinnamic acid derivative of formula Ia or Ib, or a pharmaceutically acceptable salt thereof:

Method for preventing or treating elevated blood lipid level-related diseases by administering cinnamic acid derivatives

Methods for inhibiting the activity of acyl CoA-cholesterol-o-acyltransferase, inhibiting the accumulation of macrophage-lipid complex on the arterial endothelium, and preventing or treating hepatic diseases in a mammal comprise administering naringin or naringenin thereto.

Naringin and naringenin as inhibitors of acyl

A method for increasing the plasma high density lipoprotein(HDL) level in a mammal comprises administering a bioflavonoid of formula(I) or plant extract containing same thereto: ##STR1## wherein, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5.sub.7 R.sup.6, R.sup.7, R.sup.8 and R.sup.9 are each independently hydrogen; a hydroxy group; a C.sub.1-9 alkoxy group optionally substituted with one or more substituents selected from the group consisting of a hydroxy, C.sub.1-5 alkoxy, aryloxy, and phenyl group substituted with 1 to 3 substituents selected from the group consisting of a hydroxy, alkoxy, aryloxy, halogen, nitro and amido group; a C.sub.5-9 cycloalkyloxy group substituted with 1 to 3 substituents selected from the group consisting of a hydroxy, alkoxy, aryloxy, halogen, nitro and amido group; a C.sub.5-9 cycloalkylcarbonyloxy group substituted with 1 to 3 substituents selected from the group consisting of a hydroxy, alkoxy, aryloxy, halogen, nitro and amido group; a C.sub.2-10 or C.sub.16-18 acyloxy group optionally substituted with one or more substituents selected from the group consisting of a hydroxy, C.sub.1-5 alkoxy, aryloxy, and phenyl group substituted with 1 to 3 substituents selected from the group consisting of a hydroxy, alkoxy, aryloxy, halogen and nitro group; a rutinosyl group; or a rhaminosyl group; and

Bioflavonoids as plasma high density lipoprotein level increasing agent

A method for treating or preventing an elevated blood lipid level-related diseases such as hyperlipidemia, arteriosclerosis, angina pectoris, stroke and hepatic diseases in a mammal, which comprises administering thereto an effective amount of tannin, gallic acid or ellagic acid.

Method for preventing or treating elevated blood lipid level-related

A method for lowering the blood glucose level in a mammal comprises administering an effective amount of a hesperetin or naringenin bioflavonoid.

Method for lowering blood glucose level by the administration of

A method for inhibiting the activity of 3-hydroxy-3-methylglutaryl CoA(HMG--CoA) reductase in mammals is disclosed comprising administering naringin or naringenin thereto.

Naringin and naringenin as 3-hydroxy-3-methylglutaryl CoA(HMG-CoA)

A method for inhibiting the activity of 3-hydroxy-3-methylglutaryl CoA(HMG-CoA) reductase in mammals comprises administering citrus peel extract thereto.

Citrus peel extract as 3-hydroxy-3-methylglutaryl CoA(HMG-CoA) reductase

A method for inhibiting the activity of 3-hydroxy-3-methylglutaryl CoA(HMG-CoA) reductase in mammals comprises administering hesperidin or hesperetin thereto.

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Daejeon, South Korea

Eun-Sook Lee