Korea Research Institute of Chemical Technology

Harvard College

Ewha University-Industry Collaboration Foundation

Eun Sook Hwang

Jung Nyoung Heo

Sung Youn Chang

Sung-Eun Yoo

Kyu Yang Yi

Jee Hee Suh

Nak Jeong Kim

Myung-Ae Bae

Jeong-Ho Hong

Namsook Kang

Laurie H Glimcher

Nack Jeong Kim

Sung Eun Yoo

Myung Ae Bae

Nam Sook Kang

Ui Joung Youn

Joo Won Nam

Eun Kyoung Seo

A pharmaceutical composition comprising a phenyltetrazole derivative of formula (I) or a pharmaceutical acceptable salt thereof is effective in preventing or treating osteoporosis, obesity, diabetes, or hyperlipidemia, by regulating protein TAZ.  wherein, A is ethyl or n-butyl; Ris methyl, &#x2014;CHOH, &#x2014;COCH, &#x2014;CHF, &#x2014;CH(OCH), &#x2014;CHOC(&#x2550;O)CH, styryl or &#x2014;CHOCHSCH; Ris H, Br, &#x2014;COCH, phenyl, pyridin-2-yl, pyridin-3-yl, or styryl; Ris H or methyl; X is CH or N; and P is H or &#x2014;CH(CH)OCHCH.

Pharmaceutical composition for preventing or treating osteoporosis or obesity comprising phenyltetrazole derivative

An indenone derivative of formula (1) is effective in enhancing the activity of osteoblastic cells and inhibiting bone resorption by osteoclastic cells, and a pharmaceutical composition comprising the indenone derivative or a pharmaceutically acceptable salt thereof is useful for preventing or treating bone diseases such as osteoporosis.

Indenone derivative and pharmaceutical composition comprising same

The present invention relates to a composition comprising an extract ofBunge or the compounds isolated from the same, as an active ingredient. In particular, the extract and compounds have the excellent inhibitory effects on adipocyte differentiation, and thus can be used in a pharmaceutical composition and functional food for the prevention and treatment of lipid metabolism disorders.

[object Object]

A phamaceutical composition comprising a phenyltetrazole derivative of formula (I) or a pharmaceutical acceptable salt thereof is effective in preventing or treating osteoporosis, obesity, diabetes, or hyperlipidemia, by regulating protein TAZ.  

The instant invention is based, at least in part, on the dentification of a mechanism by which T-bet modulates IL2 production. The present invention pertains to methods of identifying agents that modulate the kinase-mediated interaction of T-bet with RelA, as well as methods of use therefore.

Modulation of IL-2 production by T-bet

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Seoul, South Korea

Eun Sook Hwang