Dynebio Inc.

Kakao Corporation

Eun Joo Kim

Je Hyeon Lee

Mi Ok Kim

Sol Park

Hee Jin Lim

Sung Bum Hong

Kyoung Woon Kim

Sung Hyun Choi

Cheol Wong Kam

Yeon Hee Lee

Eun Ha Ahn

Jeong Hyun Yang

The present invention providesstrain A3(2)_M22-2C43 obtained by inducing a point mutation in the base sequence of the DagB gene in a wild-typestrain A3(2) by UV radiation. Since thestrain A3(2)_M22-2C43 according to the present invention expresses a DagB mutant enzyme expressing little or no DagB beta-agarase or exhibiting little or no beta-agarase activity, there is no need for separate isolation and purification of DagA enzymes from culture fluid, and the culture fluid of thestrain A3(2)_M22-2C43 or supernatant thereof may be used to produce, from agar or agarose, neoagarose oligosaccharides with a higher content of neoagarotetraose or neoagarohexaose than that of neoagarobiose.

mutant strain, method of producing &#x3b2;-agarase by using same, and method of producing neoagaro-oligosaccharides by using same

Provided in the present invention is a novel use of composition containing a neoagarooligosaccharide mixture as an active ingredient. The neoagarooligosaccharide mixture and the like as an active ingredient of the composition according to the present invention can reduce the expression of RANKL, an osteoclast inducer, or IL-6, an inflammatory cytokine, and effectively inhibit differentiation of monocytes into osteoclasts. Thus, the composition according to the present invention may be used as a medicine or functional food for preventing, alleviating, or treating arthritis (especially rheumatoid arthritis). Further, the active ingredient of the composition according to the present invention can be obtained by an enzyme reaction between a readily available substrate such as agar or agarose and DagA as a beta-agarase derived from. Thus, it can be produced at a relatively low cost and can easily be ingested by anyone because it has no side effects.

Composition for preventing, alleviating, or treating arthritis or osteoporosis, containing neoagarooligosaccharide

Provided is an apparatus and method for providing a chatroom for consultation. The consultation chatroom providing apparatus generates an identification code by receiving consultation meta information and partner profile information from a partner server, generates a consultation chatroom by receiving the partner profile information and user information from a user terminal that scans or receives the identification code, and pushes information about the consultation chatroom to the user terminal.

Method and apparatus of providing chatrooms for consultation

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Seongnam-si, South Korea

Eun Joo Kim