Korea Institute of Oriental Medicine

Eun Jin Shon

Jung Hyun Kim

Jong Min Kim

Joo Hwan Kim

Dae Sik Jang

Dong Ho Jung

Jin Sook Kim

Yun Mi Lee

Young Sook Kim

Chan-Sik Kim

Nam-Hee Yoo

Ohn Soon Kim

Ik Soo Lee

Ki Mo Kim

Kyu Hyung Jo

Gyu Hyeong Jo

Chan Sik Kim

Jeong Lim Yoo

The present invention relates to a pharmaceutical composition and a health functional food composition for prevention, treatment or amelioration of diabetic complications or angioedema containing a mixed extract ofleaves andas an active ingredient. More specifically, the present invention relates to a pharmaceutical composition and a health functional food composition for prevention, treatment or amelioration of diabetic complications or angioedema further containing an extract ofleaves,, blueberry, bilberry, raspberry, or grape seeds as an active ingredient, in addition to the mixed extract ofleaves and

Pharmaceutical composition and functional food comprising natural extracts for preventing or treating diabetic complications or angiodema

The present invention relates to a pharmaceutical composition for the prevention and treatment of diabetic complications comprising the extract ofLour. or the fraction thereof as an active ingredient. More particularly, the extract ofLour. or the fractions thereof of the present invention can inhibit the activity of aldose reductase and the generation of the advanced glycation endproducts, the index of diabetic complications, and have powerful activity of inhibiting diabetic complications with brining the anti-cataract, anti-retinopathy, and anti-neuropathy effect, and have the activity of anti-oxidation as well, so that they can be effectively used as an active ingredient of a pharmaceutical composition for the prevention and treatment of diabetic complications.

Pharmaceutical composition for preventing and treating complications of diabetes containing a traditional oriental medicine extract or a fraction thereof as an active ingredient

The present invention provides a novel biphenyl compound or pharmaceutically acceptable salts thereof, methods for preparing the same, and pharmaceutical compositions for preventing or treating diabetic complications containing the same as an active ingredient. Novel biphenyl compounds, according to the present invention, effectively suppress generation activity of advanced glycation end products, which cause diabetic complications and are a criterion for evaluating the effectiveness of a treating agent for diabetic complications, and show an excellent therapeutic effect on retina blood vessels, increased occludin, and decreased angiogenic growth factor in actual diabetic retinopathy induced retina. Thus, novel biphenyl compounds according to the present invention can be used effectively as an active ingredient in compositions for preventing or treating diabetic complications such as diabetic retinopathy.

Biphenyl compound or pharmaceutically acceptable salt thereof, method for preparing novel biphenyl compound or pharmaceutically acceptable salt thereof, and pharmaceutical composition containing same as active ingredient for preventing or treating diabetes complications

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Daejeon, South Korea

Eun Jin Shon