Korea Institute of Science and Technology

Eun Jin Jun

Hwan Geun Choi

Tae Bo Sim

Young Jin Ham

Jung Mi Hah

Hwan Oh Kim

Kyung Ho Yoo

Chang Hyun Oh

Jung Hun Lee

Disclosed are a 1,6-substituted indole compound having a protein kinase inhibition activity, a pharmaceutically acceptable salt, and a pharmaceutical composition for prevention and treatment of cancers caused by abnormal cell growth comprising the compound as an effective ingredient. Since the novel indole compound exhibits superior inhibition activity against various protein kinases involved in growth factor signal transduction, it is useful as an agent for preventing or treating cancers caused by abnormal cell growth.

1,6-disubstituted indole compounds as protein kinase inhibitors

Disclosed are a 2,7-substituted thieno[3,2-d]pyrimidine compound having a protein kinase inhibition activity, a pharmaceutically acceptable salt, and a pharmaceutical composition for prevention and treatment of diseases caused by abnormal cell growth comprising the compound as an effective ingredient. Since the novel 2,7-substituted thieno[3,2-d]pyrimidine compound exhibits superior inhibition activity against various protein kinases involved in growth factor signal transduction, it is useful as an agent for preventing or treating diseases caused by abnormal cell growth.

2,7-substituted thieno[3,2-d] pyrimidine compounds as protein kinase inhibitors

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Seoul, South Korea

Eun Jin Jun