Cj Cheiljedang Corporation

Daewoong Pharmaceutical Co., Ltd.

Eun Ji Koh

Kwang Ho Lee

Ji Sun Lee

Soo An Shin

Sung Hoo Jhon

Young Bin Hwang

Seung Chul Lee

Chul Ha Kim

Mi Ryeong Han

Chun Ho Lee

Deok Ki Eom

Jae Yeong Ju

Yeon Im Lee

The present invention provides a 4-methoxy pyrrole derivative or a pharmaceutically acceptable salt thereof, a preparation method thereof, and a pharmaceutical composition containing the same. The 4-methoxy pyrrole derivatives or pharmaceutically acceptable salts thereof according to the present invention have not only excellent proton pump inhibitory activity, gastric damage-inhibiting activity and defensive factor-enhancing effects, but also excellent eradication activity against. Therefore, the 4-methoxy pyrrole derivatives or pharmaceutically acceptable salts thereof can be effectively used for the prevention and treatment of gastrointestinal damage due to gastrointestinal tract ulcer, gastritis, reflux esophagitis or. Moreover, the 4-methoxy pyrrole derivatives or pharmaceutically acceptable salts thereof, have inhibitory activities against GPCR and thus can be effectively used for the prevention and treatment of 5-HT receptor-mediated or muscarinic acetylcholine receptor-mediated diseases.

4-methoxy pyrrole derivatives or salts thereof and pharmaceutical composition comprising the same

An L-threonine-producingin which a promoter of a phosphoenolpyruvate carboxylase (ppc) gene on the chromosome is substituted with a promoter of a cysteine synthase (cysK) gene and a method of producing L-threonine by using the same are disclosed. The recombinantmay produce L-threonine in a high yield, and thus may be widely used in medical, pharmaceutical, and feed industries, particularly for an animal feed.

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Gyeonggi-do, South Korea

Eun Ji Koh