Yuhan Corporation

The Green Cross Corporation

Eui-Chul Lee

Dong-Hoon Kim

Ho-Woong Kang

Chan-Sun Park

Tae-Dong Han

Su-Youn Nam

Jae-Eun Joo

Jong-Gyun Kim

Jin-Hwi Park

Dong-hyun Kim

Young-hwan Kim

Se-Woong Oh

Eun-Hye Jung

Youn Hur

Sang-Ho Ma

Ji-Yeong Gal

Jun-Chul Park

Hyok-Jun Cho

Won-Ee Chong

Su-Bin Choi

Seung-Yub Shin

Ick-Hwan Son

Sool-Ki Kwon

Young-Gyu Kong

Ji-Hye Kim

Provided are a compound having a 1,2,3,4-tetrahydronaphthalene moiety or pharmaceutically acceptable salt thereof, of Formula 1 a pharmaceutical composition comprising the same and a use thereof, where the compound having a 1,2,3,4-tetrahydronaphthalene moiety or pharmaceutically acceptable salt thereof has an inhibitory activity against glucosylceramide synthase (GCS), and therefore can be usefully applied for preventing or treating various diseases associated with GCS, such as Gaucher disease, Fabry disease, Tay-Sachs disease, Parkinson's disease, etc.

Derivatives having 1,2,3,4-tetrahydronaphthalene moiety or pharmaceutically acceptable salt thereof and pharmaceutical compositions comprising the same

The present invention provides a quinazoline derivative or its pharmaceutically acceptable salt, a process for the preparation thereof, a pharmaceutical composition comprising the same and a use thereof. The quinazoline derivative or its pharmaceutically acceptable salt has a selective inhibitory activity against the phosphatidylinositol 3-kinase delta subunit, and therefore can be usefully applied for preventing or treating cancer, along with avoiding side effects such as lymphopenia-associated inflammatory responses.

Quinazoline derivative or its salt and pharmaceutical composition comprising the same

The present invention provides a benzo[d]thiazole derivative or its pharmaceutically acceptable salt, a process for the preparation thereof, and a pharmaceutical composition comprising the same. The benzo[d]thiazole derivative or its pharmaceutically acceptable salt can selectively inhibit the protein-protein interaction between KRS and a laminin receptor (LR), thereby inhibiting migration of cancer cells. Therefore, the benzo[d]thiazole derivative or its pharmaceutically acceptable salt may be usefully applied for preventing or treating the diseases associated with cancer cell metastasis.

Benzo[d]thiazole derivative or salt thereof, and pharmaceutical composition including same

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Yongin-si, South Korea

Eui-Chul Lee