Mogam Biotechnology Research Institute

Yonsei University

The Green Cross Corporation

Mogam Institute for Biomedical Research

Eui-Cheol Jo

Kyuhyun Lee

Seongtae Yun

Daekyung Koh

Hyeon Bum Lee

Hong-Kyu Lee

Yong Jae Kim

Seung-Hoon Lee

Jin-Hyun Park

Chae-Ok Yun

Doo-Hong Park

Mihee Hwang

Yeup Yoon

Mee Sook Oh

Jang-Seong Kim

Jin-Hyung Ahn

Ho-Jeong Lee

Jae Hwan Ryu

So Ra Kim

Injae Oh

Seong-Tae Yun

A chimera protein according to the present application has a significantly increased in vivo half-life when administered because of a vWF domain coupled to FVIII, such that when used as a hemophilia A therapeutic agent, convenience for patients can be increased and medical expenses can be reduced.

Chimera protein comprising FVIII and vWF factors, and use thereof

Novel hexon isolated from simian adenovirus serotype 19 encoded in the polynucleotide defined as SEQ ID NO: 3, hepervariable region thereof, chimeric adenovirus comprising the same, and therapeutic use thereof provides a solution to the problem of safety and effective systemic treatment for developing gene therapeutic agents using adenovirus.

Hexon isolated from simian adenovirus serotype 19, hypervariable region thereof and chimeric adenovirus using the same

Provided are tumor-specific promoters, oncolytic virus vectors and a pharmaceutical composition comprising the virus vector. The virus vector comprising the novel tumor-specific promoter shows excellent oncolytic effects on tumor cells, and thus it is useful for treating a cancer.

Tumor specific promoter and oncolytic virus vector comprising the same

Provided is an expression vector for gene therapy having a novel combination of transcriptional regulatory elements, including a promoter, an enhancer, an intron, an untranslated region (UTR) and a locus control region (LCR). The expression vector enables sustained expression of a liver tissue-specific gene, and thus, can be effectively used for treating thrombosis, hemophilia, liver cancer, etc.

Expression vector suitable for expression of a coding sequence for gene therapy

Expression vector for gene therapy

Growing community of inventors

Yongin-si, South Korea

Eui-Cheol Jo