Dna Medicine Institute, Inc.

US Genomics, Inc.

Life Technologies Corporation

Pathogenetix, Inc.

Other

Princeton University

Eugene Y Chan

Marcus Atkin

Parris S Wellman

Lance C Gleich

Martin Fuchs

Rudolf Gilmanshin

Julia Z Sharpe

Jeffrey D Randall

Dexter Eames

Xiaojian (David) Zhao

Bijit Kundu

Jessica Kesty

Moon Z Chan

Robert H Austin

Jonas O Tegenfeldt

Steven R Gullans

Jenny Ellen Rooke

Steve R Gullans

Moon Bae

Kee Seok Jeon

Mark Nadel

Medical consumable device

Medical diagnostic device

Medical sample collector device

A sample consumable that carries a microvolume of sample to a sample loader. The consumable is precisely aligned utilizing a double-alignment feature to the loader. The loader is based on a crank-slider geometry and allows for simple, one-handed operation for the user. Overall, the consumable and sample loader increase reproducibility of in-line sample loading and offers ease-of-use.

Sample consumable and loader

An integrated vitals device capable of acquiring multiple data streams, allowing for comprehensive measurement of whole health status using a single, compact device. This allows for simplification of traditional healthcare delivery where multiple devices are required for acquisition of vital signs. A sensor stack up, occupying the approximate physical footprint and volume allows this approach to be possible. This application describes how these simultaneous vitals data streams can be acquired using an integrated device with small mass and volume.

Multi-channel vitals device

A system for collection and delivery of sub-milliliter liquid samples is described that provides a dramatic simplification for the measurement of clinical values. The system produces high dilutions of capillary size samples, such as bodily fluids or blood, by a factor of 1000 or more. Multiple assays can be conducted on a sample of 0.1 cc or less. A small lancet can create a drop of blood on a fingertip or other location, which can be collected into a self-priming capillary blood collector. The sample is then loaded into a consumable loader. Then a fluid, such as saline, is flowed into the consumable loader, and passes through the capillary collector, washing out the fluid. Downstream, the blood in the capillary is reliably diluted by mixing with appropriate reagents to allow analysis of selected blood properties. One or more individual bubbles can be inserted into the stream during loading. The capillary loading system can be used for one or several assays on a single blood sample. It can be very compact and lightweight and is suitable for use in remote environments, such as outer space, in which it is difficult to access diagnostic assays.

Capillary manipulation of clinical samples

The stable and precise incorporation of multiple fluorescent dyes into hydrogel microparticles. The multiple fluorescent dyes, excited with the same source, have distinct fluorescence emission spectra to enable identification of the microparticles. The fluorescent molecules are directly polymerized into the hydrogel matrix or stably incorporated through molecular entanglement. By changing the molar ratios of the fluorescent dyes, different and identifiable microparticles can be synthesized.

Multi-dye microparticles

Multiplexing microparticles by measurement of particle length and dye. Utilization of length-based measurements in combination with dye concentrations to attain multiplexing for bioassays.

Microparticle multiplexing

An integrated fluidics module that reduces mass and volume so that it can readily fit inside a compact biomedical instrument. A fluidics module that integrates discrete components (e.g., pump, connectors, tubing, regulator, and valves) reduces mass and volume requirements.

Fluidics module

Vital sign instrument

An integrated optical block that is highly portable and compact, designed to measure cells and particles.

Optical block

Methods and products for analyzing polymers are provided. The methods include methods for determining various other structural properties of the polymers.

Methods and products for analyzing polymers

Sample consumable

Growing community of inventors

Boston, MA, United States of America

Eugene Y Chan