Yeda Research and Develpment & Co. Ltd

Eugene Varfolomeev

David Wallach

Igor Mett

Mark Boldin

Andrei Kovalenko

Cord Brakebusch

Tanya Goncharov

Zeev Pancer

Yura Goltsev

Michael Batkin

Vadim Brodianski

Proteins capable of modulating or mediating the function of MORT-1 are disclosed. Also disclosed are DNA sequences encoding these proteins, the recombinant production of these proteins as well as their use.

CASH (Caspase Homologue) with death effector domain, modulators of the function of FAS

Cash (caspase homologue) with death effector domain, modulators of the function of FAS receptors

Proteins capable of modulating the function of FAS/APO1 are provided. The proteins may be prepared by culturing a host cell transformed with a vector containing the DNA encoding such a protein under suitable conditions and isolating the protein.

Modulators of the function of FAS/APO1 receptors

The present invention generally concerns novel proteins which bind to the intracellular domains of the p55 and p75 TNF-Rs and the FAS-R, which are capable of modulating the function of the p55 and p75 TNF-Rs and the FAS-R, and the DNA sequences which encode them. The present invention also concerns new soluble oligomeric TNF-Rs, oligomeric FAS-Rs and oligomeric receptors having a mixture of TNF-Rs and FAS-Rs. In addition, the present invention concerns methods of preparation and uses of all of the aforementioned.

Modulator of TNF/NGF superfamily receptors and soluble oligomeric TNF/NGF superfamily receptors

Modulators of the function of FAS/AP01 receptors

A modulator of regulatory cellular events occurring intracellularly which are mediated by regulatory proteins containing a 'death domain' motif is provided. The 'death domain' is a regulatory portion of the regulatory proteins, and the modulator is capable of interacting with one or more &#x2018;death domain&#x2019; motifs contained in the regulatory proteins and affecting the regulatory action of one or more of the regulatory proteins. The modulator preferably is capable of interacting with &#x2018;death domain&#x2019; motifs within p55-TNF-R, FAS/APO1-R, NGF-R, MORT-1, RIP, TRADD, or ankyrin. A method for producing the modulators is also provided. The modulators are useful for modulating functions mediated in cells by proteins containing the &#x2018;death domain&#x2019;.

Modulators of regulatory proteins

A modulator of regulatory cellular events occurring intracellularly which are mediated by regulatory proteins containing a &ldquo;death domain&rdquo; motif is provided. The &ldquo;death domain&rdquo; is a regulatory portion of the regulatory proteins, and the modulator is capable of interacting with one or more &ldquo;death domain&rdquo; motifs contained in the regulatory proteins and affecting the regulatory action of one or more of the regulatory proteins. The modulator preferably is capable of interating with &ldquo;death domain&rdquo; motifs within p55-TNF-R, FAS/APO1-R, NGF-R, MORT-1, RIP, TRADD, or ankryin, as illustrated in the Figure. A method for producing the modulators is also provided. The modulators are useful for modulating functions mediated in cells by proteins containing the &ldquo;death domain&rdquo;.

Antibodies to the death domain motifs of regulatory proteins

Molecules which influence the shedding of the cell-bound p55 Tumor Necrosis Factor receptor (p55-TNF-R), are provided, together with methods of producing them.

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Rehovot, Israel

Eugene Varfolomeev