Oklahoma State University

Research Corporation Technologies, Inc.

Eugene S Patterson

Benjamin J Scherlag

Kenneth D Berlin

Subbiah Sangiah

Ralph Lazzara

Cyril Roy Clarke

Gregory Lynn Garrison

Chun-Lin Chen

George Edward Burrows

Edgar A O'Rear

Arthur E Johnson

Thomas L Whitsett

Philip D Nguyen

3,7-Diazabicyclo�3.3!nonanes and selected derivatives thereof of the general formula: ##STR1## wherein Q=S; Z=CH.sub.2 ; and Y equals an N-acyl or N-alkyl group are disclosed as multiclass antiarrhythmic agents.

N-alkyl and N-acyl derivatives of 3,7-Diazabicyclo-�3.3.1!nonanes and

A composition comprising a plurality of microcapsules suitable for parenteral injection into a mammal comprising a plasminogen activator-containing core, and a semi-permeable biocompatible layer surrounding the core permitting controlled release of at least a portion of the plasminogen activator. A method of reducing the time required for reperfusion of an artery containing a thrombus and a method to reduce the standard dosage requirement of a plasminogen activator in a mammal comprising intravenous injection of a composition comprising a plurality of microcapsules comprising a plasminogen activator core surrounded by a controlled release semi-permeable layer.

Method and composition for the treatment of thrombosis in a mammal

3,7-Diazabicyclo[3.3.1]nonanes and selected derivatives thereof of the general formula: ##STR1## are disclosed as multiclass antiarrhythmic agents.

N-alkyl and n-acyl derivatives of 3,7-diazabicyclo-[3.3.1]nonanes and

Growing community of inventors

Oklahoma City, OK, United States of America

Eugene S Patterson