The United States of America, As Represented by the Secretary, Department of Health and Human Services

Eugene Major

Avindra Nath

Laura B Jaeger

Michael W Ferenczy

Caroline Ryschkewitsch

Maria Chiara Kushner-Monaco

Michael William Ferenczy

The instant invention provides compositions and methods for inhibiting the JC Virus (JCV), and that can be used, for example, for treating progressive multifocal leukoencephalopathy (PML). Antisense oligonucleotides are provided which are effective in inhibiting JCV replication or multiplication, alone or in a combination. In preferred embodiments, the oligonucleotides contain modifications.

Compositions and methods for inhibiting JC virus (JCV)

The disclosure relates to methods and compositions for detecting the presence of Prototype and/or Archetype JC virus in a biological sample from a subject. In some embodiments, the methods include amplifying and detecting a first nucleic acid sequence unique to Archetype JC virus in a biological sample, and a second nucleic acid sequence common to both Archetype and Prototype JC virus in the biological sample. In several embodiments, the methods can be used to identify JC virus in a biological sample from a subject at risk for progressive multifocal leukoencephalopathy. Compositions and kits for use in the disclosed methods are also provided.

Methods and compositions for identifying JC virus

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Darnestown, MD, United States of America

Eugene Major