Korea Institute of Science and Technology

Ajou University Industry-Academic Cooperation Foundation

Eugene Lih

Kyung Min Park

Dong Keun Han

Ki Dong Park

Yoon Ki Joung

Yunki Lee

Yun Ah Kim

Bae Young Kim

Jin Woo Bae

Provided is an organic/inorganic hybrid-porous biodegradable polymer scaffold, which includes basic ceramic nanoparticles, an animal tissue or cell-derived bioactive first extracellular matrix material, and a biodegradable polymer and in which inner walls of pores are coated with a second extracellular matrix material.

Organic/inorganic hybrid-biodegradable porous polymer scaffolds and preparation method thereof

The present invention relates to a method for preparing a hydrogel, including the steps of: preparing an enzyme-immobilized support; making contacting with a polymer having a phenol or aniline functional group at a side change and the support in the presence of hydrogen peroxide to cross-link the same; and obtaining a hydrogel by separating the enzyme-immobilized support. According to the present invention, a hydrogel is formed by cross-linking a polymer having a phenol or aniline functional group at a side chain through an enzyme-immobilized support, and thus a hydrogel containing no enzymes is obtained. Therefore, the biomedical application range of a hydrogel can be expanded since it is possible to overcome an in vivo safety problem such as immune reaction caused by an enzyme.

Method for preparing in situ-formed hydrogel using enzyme-immobilized support, and biomedical use thereof

Growing community of inventors

Seoul, South Korea

Eugene Lih