Merck + Co., Inc.

Eugene L Dulaney

Sheldon B Zimmerman

Nathaniel Grier

David Penman Jacobus

Thomas W Miller

Mary E Valiant

Sara A Currie

James P Springer

Otto D Hensens

Sagrario M Del Val

Jerrold M Liesch

Richard L Monaghan

Kenneth E Wilson

John G Ondeyka

Carol F Wichmann

Richard W Burg

August J Kempf

Sagrario Mochales Del Val

L-654,040 of the structure: ##STR1## is a novel antibacterial and isolated from the novel organism Streptoverticillium synroense, strain MA6011, deposited at the ATCC.

L-654,040, antibacterial agent

Process for producing L-654,040, antibacterial agent

The novel organism Streptoverticillium synroense, strain MA6011, deposited at the ATCC under Accession No. ATCC 53699 produces a novel antibacterial of the structure: ##STR1##

Culture of Streptoverticillium synroense for producing an antibacterial

There are disclosed anti-inflammatory and antidegenerative compounds which are natural products produced by cultivation of sail microorganism L-681,512 under controlled fermentation conditions.

Anti-inflammatory and antidegenerative compounds isolated from L-681,512

The antibiotic, L-681,217, having antibacterial and growth-permittant activity, is produced by fermentation of Streptomyces cattleya in a suitable nutrient media.

Discovery of antibiotic L-681,217 in fermentation broth

A composition comprising tris-(hydroxymethyl)aminomethane and dicyclohexyl-, dicyclohexenyl- and cyclohexylcyclohexenyl-alkyl polyamines, their acid addition salts, and mixtures thereof are useful as antibacterial agents. The composition is particularly useful because of the synergistic improvement obtained against strains of the genus Pseudomonas, as well as other genera.

Broad spectrum antibacterial compositions containing

A composition comprising tris-(hydroxymethyl)aminomethane and diphenyl and loweralkyl substituted diphenyl polyamines, their acid addition salts, and mixtures thereof are useful as antibacterial agents. The composition is particularly useful because of the synergistic improvement obtained against strains of the genus Pseudomonas, as well as other genera.

Broad spectrum antibacterial compositions containing tris

A composition comprising tris-(hydroxymethyl)aminomethane and dibicyclo [3.1.1] and [2.2.1] heptyl and dibicyclo [3.1.1] and [2.2.1] heptenyl polyamines, their acid addition salts, and mixtures thereof are useful as antimicrobial agents. The composition is particularly useful because of the synergistic improvement obtained against strains of the genus Pseudomonas, as well as other genera.

Growing community of inventors

Summit, NJ, United States of America

Eugene L Dulaney