Wyeth Holdings Corporation

Pfizer Corporation

Eugene Joseph Vidunas

Mark Edward Ruppen

Justin Keith Moran

Andrew George Popplewell

John W Simpson

Nitin Krishnaji Damle

Arthur Kunz

Joseph Thomas Rubino

John Francis DiJoseph

Nishith Merchant

Neera Jain

Paul David Robbins

Kathrin Ute Jansen

Annaliesa Sybil Anderson

Deborah Ann Dilts

John McLean Simpson

Arthur Kuntz

In one aspect, the invention relates to an isolated polypeptide including the amino acid sequence of a carrier polypeptide and the amino acid sequence of an ORF2086 polypeptide. In another aspect, the invention relates to an immunogenic conjugate including ORF2086 polypeptide and a carrier polypeptide. The invention further includes immunogenic compositions and methods for inducing an immune response againstin a mammal.

Immunogenic fusion polypeptides

Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.

Calicheamicin derivative-carrier conjugates

Growing community of inventors

Middletown, NY, United States of America

Eugene Joseph Vidunas