Gilead Sciences, Inc.

Eugene J Eisenberg

Richard L Mackman

Dustin S Siegel

Hon Chung Hui

Jay P Parrish

Oliver L Saunders

Michael Sangi

Constantine G Boojamra

David Sperandio

Hai Yang

Kerim Babaoglu

William A Lee

John C Rohloff

Ernest J Prisbe

Tomas Cihlar

Gong-Xin He

Mark L Sparacino

Michael R Kernan

Harlan H Chapman

Mark W Becker

Dustin Siegel

The invention provides compounds of Formula I or Formula II: or a pharmaceutically acceptable salt or ester, thereof, as described herein. The compounds and compositions thereof are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections.

Pyrazolo[1,5-A]pyrimidines for antiviral treatment

The invention provides compounds of Formula I or Formula II: 

Pyrazolo[1,5-a]pyrimidines for antiviral treatment

A novel method has led to the identification of novel mixed ester-amidates of PMPA for retroviral or hepadnaviral therapy, including compounds of structure (5a) having substituent groups as defined herein. Compositions of these novel compounds in pharmaceutically acceptable excipients and their use in therapy and prophylaxis are provided.

Prodrugs of phosphonate nucoleotide analogues

Prodrugs of phosphonate nucleotide analogues

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San Carlos, CA, United States of America

Eugene J Eisenberg