Sandoz Gmbh

Sandoz Ltd., (sandoz Ag)

Eugene E Galantay

Faizulla G Kathawala

Robert V Coombs

Dietmar A Habeck

Heribert Wagner

The compounds are 4-phenyl-4-lower alkyl-substituted-3-buten-2-ones, and -2-halo-1,3-butadienes, e.g., 2-(p-biphenylyl)-2-penten-4-one, and are useful as pharmaceuticals.

1-Alkyl, 1-phenyl-butenes

1-Alkyl,1-phenyl-butenes

Disclosed are compounds of the class 1-phenyl-2,3-butadien-1-ol e.g. 2-(p-biphenylyl)-3,4-pentadien-2-ol, which are useful by reason of their pharmacological activity in animals, e.g., as anti-inflammatory agents and tranquilizers. Said compounds can be prepared, e.g., by reduction of a corresponding 4-substituted-1-phenyl-2-butyne-1-ol with a complex hydride such as lithium aluminum hydride.

1-Phenyl-2,3-butadien-1-ols and method of use

Disclosed are compounds of the class 1-phenyl-2,3-butadien-1-ol e.g. 2-(p-biphenyl)-3,4-pentadien-2-ol, which are useful by reason of their pharmacological activity in animals, e.g., as anti-inflammatory agents and tranquilizers. Said compounds can be prepared, e.g., by reduction of a corresponding 4-substituted-1-phenyl-2-butyne-1-ol with a complex hydride such as lithium aluminum hydride.

P-(substituted and unsubstituted-phenyl)-1-phenyl-2,3-butadien-1-ols as

The compounds are 4-aryl substituted buta-2,3-dienoic acids and esters thereof which may also be lower alkyl-substituted at any of the 2- and 4- positions, e.g., 4-(p-methoxyphenyl)-2-methyl-buta-2,3-dienoic acid. The compounds are useful as pharmaceuticals, e.g., as antiinflammatory agents and hypolipidemic agents.

Hypolipidemic allene carboxylic esters

Anti-inflammatory 1-phenyl-2,3-butadien-1-ols, methods of use and

The compounds are 4-aryl substituted buta-2,3-dienoic acids and esters thereof which may also be lower alkyl-substituted at any of the 2- and 4-positions, e.g., 4-(p-methoxyphenyl)-2-methyl-buta-2,3-dienoic acid. The compounds are useful as pharmaceuticals, e.g., as anti-inflammatory agents and hypolipidemic agents.

Hypolipidemic allene carboxylic acids

The compounds are 13-(lower)alkyl-9.alpha.-methyl-17.alpha.-propadienylgona-4-en-17.beta.-ol -3-ones and derivatives thereof, e.g. 9.alpha.-methyl-17.alpha.-propadienylestra-17.beta.-ol-3-one, and are useful as progestational agents.

9-.alpha.-methyl-steroids

Disclosed are compounds of the class 1-naphthyl-2,3-butadien-1-ol e.g. 2-(6'-methoxy-2-naphthyl)-3,4-pentadien-2-ol, which are useful by reason of their pharmacological activity in animals, e.g. as anti-inflammatory agents. Said compounds can be readily prepared by reduction of a corresponding 4-substituted-1-naphthyl-2-butyne-1-ol with a complex hydride such as lithium aluminium hydride.

1-(2-Naphthyl)-2,3-butadien-1-ols

13-alkyl-17.alpha. -propadienylgona-4,9-dien-17.beta. -ol-3-ones and their 17.beta. -oxygenated derivatives are useful in control of fertility and estrus or the menstrual cycle in warm blooded animals.

Substituted carbinol derivatives

The invention concerns novel unsaturated fatty acids useful as inhibitors of prostoglandin synthetase.

Growing community of inventors

Liestal, Switzerland

Eugene E Galantay