Mayo Foundation for Medical Education and Research

Other

Eugene D Kwon

Lieping Chen

Scott E Strome

Haidong Dong

Christopher J Krco

Svetomir N Markovic

Daniel S Nam

Xin Liu

Susan M Harrington

Lieping Cheng

John C Cheville

A toothpaste product that is laced with, or infused with, a sedative such as the active ingredients in cannabis. The act of brushing one's teeth using the present invention transfers the sedative into the bloodstream through contact with the gums, leading to a more restful sleep.

Sedative laced toothpaste

The invention features methods of diagnosis by assessing B7-H1 expression in a tissue from a subject that has, or is suspected of having, cancer, methods of treatment with agents that interfere with B7-H1-receptor interaction, methods of selecting candidate subjects likely to benefit from cancer immunotherapy, and methods of inhibiting expression of B7-H1.

Costimulatory B7-H1 in renal cell carcinoma patients: indicator of tumor aggressiveness and potential therapeutic target

Materials and methods for treating cancer, including materials and methods for treating cancer in patients identified as having elevated levels of Bim.

Methods for treating cancer in patients with elevated levels of Bim

Materials and methods for treating cancer especially in patients identified as having elevated levels of Bim are disclosed. Specifically, the disclosure provides a method for treating a mammal having cancer, the method comprises: (a) identifying said mammal as containing an elevated level of Bim, and (b) administering to said mammal an anti-B7-H1 antibody, an anti-PD-1 antibody, an anti-CD80 antibody, or a fusion protein comprising a portion of PD1 or a portion of CD80, under conditions wherein the interaction of naturally occurring B7-H1 with PD-1 or CD80 in said mammal is reduced after said administering.

Methods for treating cancer in patients with elevated levels of BIM

This document provides methods and materials involved in treating cancer. For example, methods and materials for identifying a mammal as having an elevated level of PD-1/CD11aCD8 T cells having the potential to exert anti-cancer effects are provided. In addition, methods and materials for identifying a mammal as having an elevated level of PD-1/CD11aCD8 T cells and administering a PD-1 inhibitor to such a mammal are provided.

Methods and materials for treating cancer

Methods of evaluating patients by assessing expression of B7-H4 in the vasculature are described.

Growing community of inventors

Rochester, MN, United States of America

Eugene D Kwon