American Cyanamid Company

Eugene A Carpentier

Madurai G Ganesan

Narendra Raghunathji Desai

Edward C Shinal

James Elwood Krueger

Lipid emulsion form compositions have been formulated and presented to eliminate adverse injection site reactions associated with the intravenous administration of certain sparingly water soluble, hydrophobic, ionizable drugs in mammals and to provide a solubilized drug form for oral, parenteral or intraarticular administration which enhances drug absorption and the therapeutic efficacy of the drug.

Emulsion compositions for administration of sparingly water soluble

This disclosure describes quick breaking, in vivo, intravenous, intramuscular, intraarticular fat emulsion compositions which incorporate the use of benzyl alcohol as a consurfactant and/or a cosolvent in combination with materials such as synthetic surfactants, e.g. sorbitan triisostearate, triglycerol diisostearate or triglycerol pentaoleate; naturally occurring vegetable oils, e.g. sesame oil, and soybean oil; natural lecithins such as egg lecithin or soy lecithin; saturated or unsaturated aliphatic acids, e.g. oleic acid, hexanoic acid and linolenic acid; and other excipients such as glycerine, polyvinylpyrrolidone, Pluronic.RTM. F-68 and di-.alpha.-tocopherol.

Emulsion compostions for the parenteral administration of sparingly

A composition of matter in pharmaceutical dosage form comprising an amorphous coprecipitate of water-soluble polyhydroxylic organic compounds and 4-(monoalkylamino)-benzoic acid and derivatives for the treatment of atherosclerosis and hyperlipidemia.

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Spring Valley, NY, United States of America

Eugene A Carpentier