Axiogenesis Ag

Ncardia Ag

Eugen Kolossov

Heribert Bohlen

Ralf Kettenhofen

Andreas Ehlich

Silke Schwengberg

Jürgen Hescheler

Bernd Fleischmann

Leo Fink

Wilhelm Röll

Jessica Königsmann

Isabella Kopp

Melanie Scholz

Wilhelm RÖLL

Juergen Hescheler

Jessica Koenigsmann

Wilhelm Roell

Jurgen Hescheler

Provided are functional cell and tissue assay systems based on substrate-integrated multifunctional microelectrode arrays implementing stem cell technology. The system covers normal and pathogenic characteristics.

Non-invasive, in vitro functional tissue assay systems

Provided are embryonic stem (ES) cell-derived tissue modeling systems. In particular, systems for the de novo generation of tissue by parallel drug selection of cell types constituting the tissue of interest in one culture of differentiating ES cells is described as well as the use of such systems in transplantation and drug development.

Tissue modeling in embryonic stem (ES) cell system

Provided are means and methods for producing embryoid bodies (EBs) from multi- or pluripotent cells. In particular, a method of generating embryoid bodies (EBs) is described comprising agitation of a liquid suspension culture of multi- or pluripotent cells in a container until generation of cell aggregates, optionally diluting the suspension, and further agitation of the suspension until formation of EBs. Furthermore, the present invention relates to the use of the novel culturing method and EBs obtained thereby for a variety of applications including genomics, diagnostic assays, teratogenic/embryotoxicological and pharmacological assays as well as for the provision of tissue grafts.

Method for the preparation of embryoid bodies (EBs) and uses thereof

Growing community of inventors

Kö'ln, Germany

Eugen Kolossov