Clondiag Gmbh

Clondiag Chip Technologies Gmbh

Blink Ag

Alere Technologies Gmbh

Abbott Rapid Diagnostics Jena Gmbh

Eugen Ermantraut

Torsten Schulz

Thomas Kaiser

Thomas Ullrich

Thomas Ellinger

Jens Tuchscheerer

Katrin Steinmetzer

Ralf Bickel

Johann Michael K&ouml;hler

Stephan Hubold

Horst Boessneck

Klaus Wohlfart

Thomas Uhlig

Alexander Von Schenk Zu Schweinsberg

Klaus-Peter Möbius

Ralf Ehricht

Daniel Weicherding

Alrik Wolff

Siegfried Poser

Klaus Peter Möbius

Vico Baier

Stefan W&ouml;lfl

Anke Wöstemeyer

Joachim Fischer

Horst Bösneck

Andreas Stärker

Gerd Wagner

Ivan Loncarevic

Jens Tuchscherer

Alexandra Dworrak

Nancy Holzhey

Frank Plenz

Anke Woestemeyer

Anke WÖSTEMEYER

Annette Wagenhaus

Karin Adelhelm

Klaus-Peter Moebius

Matthias Kirst

Stefan Dees

Ines Labugger

Vico Beier

Oliver Lemuth

Lea Kanitz

The present invention relates to a sensor body for binding and/or enriching an analyte. Furthermore, the present invention relates to a method of binding an analyte to a sensor body. Furthermore, the present invention also relates to a method of enriching and/or washing an analyte bound to a sensor body and to a method of detecting an analyte in a sample. Moreover, the present invention relates to a device for binding and/or enriching and/or detecting an analyte in a sample.

Sensor body for binding and/or enriching and/or detecting an analyte in a sample

The present invention relates to a device for fractionating a suspension sample and to uses of such device. Furthermore, the present invention also relates to a method of fractionating a suspension sample into a liquid phase and a solid phase. The present invention also relates to a device and method for separating a sample comprising a solvent and two or more components having different molecular weights and being dissolved in said solvent, into said two or more components.

Device for fractionating a suspension sample

The present invention relates to a liquid handling and processing tool for analyzing a biological sample. Furthermore, the present invention relates to a fluid processing and detection module for processing a liquid sample and for detecting analyte in the sample.

Liquid handling and processing tool for analyzing a biological sample

The present invention relates to a sample cartridge for incubating and/or analyzing a dispersion of particles, cells or droplets and/or for performing biochemical reactions with or in such dispersion. The present invention furthermore relates to a device for incubating a dispersion of particles, cells or droplets and/or for performing a biochemical reaction therewith. Moreover, the present invention also relates to the use of a sample cartridge or of a device for generating and/or processing a dispersion of particles, cells or droplets. Moreover, the present invention relates to a method of processing a dispersion of particles, cells or droplets. Furthermore, the present invention relates to a method of generating a dispersion of droplets and to a method of generating a dispersion of solid or semi-solid particles.

Sample cartridge for incubating and/or analyzing a dispersion of particles, cells or droplets

The present invention relates to a prefabricated microparticle for performing detection, preferably a digital detection and/or quantitation of an analyte. Furthermore, it also relates to a detection and/or quantitation of multiple analytes by prefabricated microparticles. It also relates to a collection of such prefabricated microparticles and to the use of such microparticle(s) and/or of such collection. Furthermore, the present invention also relates to a method of performing a detection and/or quantitation of an analyte in a sample wherein a microparticle or collection of microparticles are used. In one embodiment, in the collection of microparticles, individual microparticles are tailored for the detection of specific analytes and can be distinguished from each other by a specific label indicating the respective analyte for which the individual microparticle is specific.

Prefabricated microparticle for performing a detection of an analyte

A method for assaying a sample for each of multiple analytes is described. The method includes contacting an array of spaced-apart test zones with a liquid sample (e.g., whole blood). The test zones disposed within a channel of a microfluidic device. The channel is defined by at least one flexible wall and a second wall which may or may not be flexible. Each test zone comprising a probe compound specific for a respective target analyte. The microfluidic device is compressed to reduce the thickness of the channel, which is the distance between the inner surfaces of the walls within the channel. The presence of each analyte is determined by optically detecting an interaction at each of multiple test zones for which the distance between the inner surfaces at the corresponding location is reduced. The interaction at each test zone is indicative of the presence in the sample of a target analyte.

Methods for detecting an analyte

The present invention relates to devices and methods for the qualitative and/or quantitative detection of particles. In particular, the invention relates to devices for the detection of particles, comprising a reaction chamber formed within a chamber body between a first surface and a second surface, wherein the second surface is located opposite to the first surface, and one or more displacers, wherein the distance between the first surface and the second surface is variable via the one or more displacers at least in one or more parts of the surface area of the first surface and/or second surface. The invention also relates to corresponding methods for the detection of particles.

Device and method for the detection of particles

A method includes forming a composition of matter including an amount of a reporter compound, a binding member capable of capturing the reporter compound, and an amount of a target nucleic acid capable of forming complexes with the reporter compound.

Assays

A device comprising a rigid substrate, a flexible cover element at least partially covering the substrate, a first structure formed in the substrate, adapted for accommodating liquids and adapted for releasing contents of one or more cells, spores, or viruses, the contents including the target molecules, a second structure formed in the substrate, adapted for accommodating liquids and comprising at least one binding member adapted for capturing the target molecules and for determining a value indicative for the presence and/or amount of the target molecules, a microfluidic network interconnecting at least the first structure and the second structure, and an actuator member adapted for effecting a fluid flow between the first structure and the second structure by pressing the flexible cover element against the substrate to selectively close a portion of the microfluidic network.

Assays for measuring nucleic acids

A method for assaying a sample for each of multiple analytes is described. The method includes contacting an array of spaced-apart test zones with a liquid sample (e.g., whole blood). The test zones disposed within a channel of a microfluidic device. The channel is defined by at least one flexible wall and a second wall which may or may not be flexible. Each test zone comprising a probe compound specific for a respective target analyte. The microfluidic device is compressed to reduce the thickness of the channel, which is the distance between the inner surfaces of the walls within the channel. The presence of each analyte is determined by optically detecting an interaction at each of multiple test zones for which the distance between the inner surfaces at the corresponding location is reduced. The interaction at each test zone is indicative of the presence in the sample of a target analyte. Capillary structures of the devices or used in the methods may comprise a matrix and the devices may comprise control elements and methods for assaying of sample may use corresponding controlling activities.

The present invention relates to devices and methods for performing assays, especially for determining the presence and/or amount of one or more analytes. In particular, the invention relates to a device for the detection of analytes, comprising a reversibly compressible matrix located between a first surface and a second surface, wherein the second surface is located opposite to the first surface, and wherein the distance between the first surface and the second surface is variable. The invention also relates to a corresponding method using such a device for the detection of one or more species of analytes.

Assay devices and methods for the detection of analytes

The present invention relates to devices and methods for the detection of analytes. In particular, the invention relates to methods for the qualitative and/or quantitative detection of analytes, comprising a microarray on a substrate, onto which probe molecules are immobilized on array elements, said microarray being disposed on a first surface of the device; and a detection chamber formed between the first surface including the microarray disposed thereon and a second surface, wherein the distance between the microarray and the second surface is variable, and wherein the second surface has a displacement structure.

Method and device for the detection of molecular interactions

The invention relates to a reaction vessel, a device and a method for detecting specific interactions between molecular target and probe molecules. The present invention especially relates to a reaction vessel which has a shape and size typical of a laboratory reaction vessel and in which a supporting element with probe molecules immobilized thereon on predetermined regions is arranged on its base surfaces.

Reaction vessel for carrying out array processes

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Jena, Germany

Eugen Ermantraut