Universidade Do Minho

Eugénia Sofia Da Costa Nogueira

Artur Manuel Cavaco Paulo

Ana Arminda Lopes Preto De Almeida

Andreia Ferreira Castro Gomes

Diana Isabel Pereira Guimarães

Artur Manuel Cavaco-paulo

The present invention is the use of conjugated peptide sequences for inclusion in liposomal membranes. The combination can be done with folic acid or with an antibody of folic acid receptor coupled to N-terminal peptide. The presence of these peptides conjugated to liposomal formulations allows the targeting and subsequent release of therapeutic agents and/or imaging agents to cells expressing folic acid receptor. The developed method combines the ability of liposomes in the transport and release of drugs and the specific expression of folic acid receptor on the surface of cell membranes that allow transmembrane transport mediated by specific liposomes. Thus allows the transport of therapeutic agents and/or imaging agents, which are inside the liposome, either hydrophobic or hydrophilic. The therapeutic agents can be either pharmacological compounds (active agents) or siRNAs (small interference RNA) specific to defined target genes.

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Eugénia Sofia Da Costa Nogueira