Sicor Inc.

Ettore Bigatti

Peter Lindsay MacDonald

Pierluigi Rossetto

Dario Tentorio

Zvi Harel

Gaia Banfi

Peter Lindsay Macdonald

Processes useful in the preparation of pharmaceutical compounds such as fulvestrant and processes for the preparation of fulvestrant.

Process for the preparation of 7&#x3b1;-alkylated 19-norsteroids

The present invention provides processes for preparing Palonosetron salts, especially, the hydrochloride salt and intermediates used to prepare Palonosetron salts.

Processes for preparing palonosetron salts

The invention provides a high-yield process for the preparation of letrozole having a high purity, without the need for removal of the 4-[1-(1,3,4-triazolyl)methyl]benzonitrile impurity at the intermediate stage. The invention also provides a process for the synthesis of letrozole in which formation of the impurity 4-[1-(1,3,4-triazolyl)methyl]benzonitrile during the first stage is minimized. In the process, a 4-(halomethyl)benzonitrile is reacted with a salt of 1H-1,2,4-triazole, reducing the formation of the impurity. Preferably, the preparation is conducted as a one-pot process.

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Balerna, Switzerland

Ettore Bigatti