Chemi S.p.a.

Ettore Ammirati

Lorenzo De Ferra

Mauro Anibaldi

Stefano Turchetta

Maurizio Zenoni

Paolo Brandi

Barbara Pinto

Giorgio Berardi

Simona Andreassi

Mauro Annibaldi

Luca Mandelli

Felice Stracqualursi

The present invention relates to a process for the preparation of a polysaccharide composed of D-xylose units of formula (III) linked together via beta 1,4 glycosidic bonds wherein Ris hydrogen or acetyl, Ris hydrogen, acetyl or a 4-O-methyl glucuronic acid unit, wherein, when Ris a 4-O-methyl glucuronic acid unit, the Rgroup on the same saccharide unit is defined as G, wherein G is hydrogen or acetyl, and wherein the sugar unit at the reducing end of sun such polysaccharide is xylose, lyxose or xylulose, said process comprising the following steps: selective deacetylation of xylan extracted from beech wood; and isomerization of the selectively deacetylated xylan achieved in step or the following steps: isomerization of xylan extracted from beech wood; and selective deacetylation of isomerized xylan achieved in step. The process is useful for the preparation of pentosan polysulfate or pharmaceutically acceptable salts thereof for pharmaceutical use.

Process for the preparation of polysaccharides

Described herein is a process for the synthesis of azacitidine or decitabine, comprising the silylation of azacytosine in the presence of N,O-bis-trimethylsilyl-trifluoroacetamide. Such reaction is performed in an organic solvent, preferably aprotic, even more preferably selected from among dichloromethane, dichloroethane and/or acetonitrile. According to a further aspect of the process, 2 to 3 moles of N,O-bis-trimethylsilyl-trifluoroacetamide are used per mole of azacytosine, preferably from 2.2 to 2.5.

Process for the synthesis of azacitidine and decitabine

The document describes a process for the preparation of N-Acyl-Phosphatidyl-Ethanolamine of formula (I) on an industrial scale, In which R, Rand Rare, independently from each other, saturated, monounsaturated or polyunsaturated acyls C-C, pure or mixed together, and X&#x2550;OH or OM, where M=alkaline metal or alkaline earth, ammonium or alkylammonium. The process in question allows the conversion of lecithin of synthetic or natural origin into N-Acyl-Phosphatidyl-Ethanolamine of formula (I) of high purity, using a limited molar excess of the reagent N-acyl-ethanolamine, where the acyl is as defined above for the formula (I) through reaction of transphosphatidylation in the presence of the enzyme phospholipase D and in conditions suitable for production on an industrial scale. 

Process for the production of N-acyl-phosphatidyl-ethanolamine

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Ettore Ammirati