Centre National De La Recherche Scientifique

National Institute of Health and Medical Research

Université De Versailles—saint-Quentin-En-Yvelines

Mitologics

Chiesi Farmaceutici S.p.a.

Sorbonne Université

Université Paris Diderot-Paris 7

Université De Paris

Universite Paris Cité

Université Versailles Saint-Quentin-En-Yvelines

Etienne Jacotot

Catherine Brenner

Annie Borgne-Sanchez

David Chauvier

Richard Casimir

Elodie Bosc

Dominique Rebouillat

Annie Borgne

Alain Langonne

Hervé Lecoeur

The present invention relates to a compound of formula (I): wherein P, P, Pand Pare amino acid residues or amino acid like structures. The invention also relates to a compound of formula (I) for its use as a Caspase-2 inhibitor and for its therapeutical use. It also concerns the use of a compound of formula (I) as activity base probe to selectively detect Caspase-2 activity.

Compounds and their use as selective inhibitors of caspase-2

The present invention relates to a compound of formula (I) wherein P, P, Pand Pare amino acid residues. The invention also relates to a compound of formula (I) for its use as a Caspase-2 inhibitor and for its therapeutical use. It also concerns the use of a compound of formula (I) as activity base probe to selectively detect Caspase-2 activity. 

Derivatives and their use as selective inhibitors of caspase-2

ANT-ligands having a substituted nitrogeneous heterocycle A wherein wherein wherein wherein,Ar and R2 are as above defined with respect to formula I.

Ant-ligands molecules and biological applications

The invention relates to molecules ANT-ligands having a substituted nitrogeneous heterocycle A wherein wherein wherein wherein,Ar and R2 are as above defined with respect to formula I.

ANT-ligands molecules and biological applications

The invention relates to selective new caspase-2 inhibitors that recognize caspase-2 and prevent and block its activity based on the following backbone: 2-Quinolinylcarbonyl-L-Valinyl-L-Aspartyl (methyl ester)-L-Valinyl-L-Alanyl-L-Aspartyl (methyl ester) 2,6-difluorophenyl ester SEQ ID NO:1) and derivatives thereof, SEQ ID NO:1 corresponding to formulae Ia or Ib. Application of the inhibitors for preventing and treating diseases involving caspase-2. 

Caspase-2 inhibitors and their biological applications

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Paris, France

Etienne Jacotot