Ethyl Corporation

Agfa Gevaert Nv

Innogenetics N.v.

Other

Universiteit Gent

University of Nottingham

European Community

Wetenschappelijk En Technisch Centrum Van De Belgische Textielnijverheid

Danbiosyst UK Ltd Aisha

University of Gent

Etienne Honore Schacht

Joan T Vermeersch

Jan Crommen

Marc Irene Van Damme

Bernard Delaey

Paul J Coppens

Paolo Ferruti

Guido I Hauquier

Stanley Stewart Davis

Ruth Duncan

Peter Dubruel

Allan Gerald Coombes

Myriam Vanneste

Ian Wilding

Stefan Vansteenkiste

Jan Laperre

Jean-Pierre Draye

Stefan Van Steenkiste

An Van Den Bulcke

Karel Ulbrich

Jorg Schelfhout

Leonard C W Seymour

Geert Hebbrecht

Jean Pierre Draye

A method for preparing a solid composite material comprising a structural polymer matrix and a thermo-responsive hydrogel involves

Methods and compositions for textile layers and coatings

The present invention relates to a composition comprising a biopolymer matrix comprising cross-linked vinyl-derivatives of gelatin, or co-polymerized methacrylamide modified gelatin with vinyl-modified polysaccharides, or cross-linked vinyl-substituted polysaccharide and gelatin being physically entrapped in a semi-interpenetrating network. Preferably said polysaccharide comprises dextran or xanthan. The present invention also relates to a wound dressing or a controlled release device comprising said biopolymer matrix. Preferably said matrix is in the form of a hydrated film, a hydrated or dry foam, dry fibers which may be fabricated into a woven or non-woven tissue, hydrated or dry microbeads, dry powder, or covered with a semipermeable film so as to control the humidity of the wound covered with the dressing, with the permeability chosen so as to maintain this humidity within a therapeutically optimal window.

Medicaments based on polymers composed of methacrylamide-modified gelatin

Synthetic polymer-based carrier vehicles for delivery of nucleic acid material to target cells in biological systems are made by self-assembly of the nucleic acid with cationic polymer material so as to condense the nucleic acid and form a polyelectrolyte complex and reacting the complex with hydrophilic polymer material which bonds to the complex forming a hydrophilic coating that stabilizes the complex and provides an outer protective steric shield. The carrier vehicles are useful for gene therapy.

Delivery of nucleic acid materials

Medicaments containing gelatin cross-linked with oxidized polysaccharides

According to the present invention there is provided a polymer not comprising maleic acid derivatives having acid labile groups pendant from the polymer backbone, characterized in that said pendant groups are represented by

Acid-sensitive substance and photosensitive compositions therewith

Polymer microspheres and a method of production thereof

The present invention provides a method for obtaining a lithographic printing plate comprising the steps of: (a) image-wise or information-wise exposing a photosensitive imaging element comprising on a hydrophilic surface of a support a hydrophobic photosensitive layer contiguous to said hydrophilic surface, comprising (i) a photosensitive acid precursor and (ii) a hydrophobic polymeric binder and (b) developing said exposed imaging element by the steps of: (i) laminating before or after said exposure an uppermost layer of said imaging element to a receptor layer and (ii) peeling away the receptor layer from the hydrophilic surface of the support thus transferring said hydrophobic photosensitive composition patternwise to the receptor layer, characterized in that said hydrophobic photosensitive layer comprises as photosensitive acid precursor a non-ionic photosensitive precursor of a sulphonic acid or a non-ionic photosensitive precursor of an optionally partially esterified phosphonic acid or a non-ionic photosensitive precursor of an optionally partially esterified phosphoric acid, the latter phosphonic or phosphoric acid precursors in the absence of an acid-sensitive composition of (a) low molecular weight compound(s).

Method for producing lithographic plates with imaging elements

Drug delivery agents incorporating mitomycin

Process for the preparation of azo-and /or disulfide polymer matrix drug

This invention provides a lithographic base comprising a support provided with a hardened hydrophilic layer wherein the hardened hydrophilic layer comprises a dextran or pullulan modified with a group containing amine or amide functions having at least one free hydrogen.

Lithographic base with a modified dextran or pullulan hydrophilic layer

Described are polyphosphazenes which may be represented by the general formula ##STR1## in which R is a hydroxy-substituted or protected hydroxy-substituted saturated aliphatic group, R' is a hydrocarbyl group, R' is a residue of an alpha amino acid, n is from about 50 to about 25,000, and x is a number averaging from 0.05 to 1.00 per repeating unit and y is a number averaging from 0.95 to 0.00 per repeating unit so that per repeating unit the sum of x and y is 1. Removal of the protecting group in the R moiety renders the polymers water soluble. The polymers have a controllable set of properties including degree of hydrolytic stability, permeability, hydrophilicity, and bioacceptability. They may be used in the production of hydrogels for drug release systems, plasma extenders, and biomedical implants.

Polyphosphazenes and their synthesis

A device for controlled release of one or more pharmacologically active substances within an animal which comprises (i) a body of a bioerodable solid state poly(amino acid ester) phosphazene polymer, and (ii) at least one pharmacologically active substance physically incorporated within said body. The device may comprise an implantable body in which the poly(amino acid ester)phosphazene polymer is a matrix within which such pharmacologically active substance is dispersed. Alternatively, the polymer may constitute a coating or container within which such pharmacologically active substance is physically encased--i.e., the polymer surrounds the active agent as in a capsule or in a microencapsulated form. Results of in vivo experiments using implants of poly[bis((ethyl glycino)phosphazene] containing 25% ethidium are described.

Bioerodable sustained release implants

The protecting group, Z, of protected alpha-amino acid esters of the formula

Novel dibasic acid salts and their synthesis

Growing community of inventors

Staden, Belgium

Etienne Honore Schacht