University of British Columbia

Other

Qlt Phototherapeutics, Inc.

Qlt, Inc. and

Qlt Phototherapeutices Inc.

Ethan D Sternberg

David H Dolphin

Julia G Levy

Anna M Richter

Ashok Jain

Ronald Erwin Boch

Elizabeth M Waterfield

Andrew Norman Tovey

Jack J Chow

David W C Hunt

David W Hunt

Jill Kirsten MacAlpine

Jack K Chow

Xuejun Peng

Angela M Desjardins

New compounds useful in photodynamic therapy are of the formula and their 1,4-diene isomersand the metallated and/or labeled and/or conjugated forms thereof

Ethylene glycol esters as photoactive agents

The present invention discloses novel photoactive compounds that may be crosslinked to target substrates. Methods for the preparation and use of the compounds, as well as compositions comprising them, are also disclosed.

Methods and compositions for photo-cross linking photoactive compounds to target tissue

A method for the separation of benzoporphyrin derivative mono and diacid (BPD-MA, BPD-DA) enantiomers by Laser-Induced Fluorescence Capillary Electrophoresis has been developed. The limits of detection are 2.06&#xd7;10M, and the relative standard deviation for the separation was 2.90% to 4.64%. The BPD enantiomers can be quantitatively determined in the range of 10to 10mg mL. In comparison with HPLC, CE has better resolution and efficiency. This separation method was successfully applied to the BPD enantiomers obtained from a matrix of bovine serum and from liposomally formulated material as well as from studies with rat, dog and human microsomes.

Chiral separation of benzoporphyrin derivative mono-and di-acids by laser-induced fluorescence capillary electrophoresis

Methods of modifying polypyrrolic macrocycles by use of a 1,3-dipolar cycloaddition is described. The methods may be used to produce compounds for further derivatization to produce photosensitizing agents of interest.

1,3-dipolar cycloadditions to polypyrrolic macrocycles

Methods of modifying polypyrrolic macrocycles by use of a 1,3-dipolar cycloaddition are described. The methods may be used to produce compounds for further derivatization to produce photosensitizing agents of interest.

1,3-Dipolar cycloadditions to polypyrrolic macrocycles

A method for the separation of benzoporphyrin derivative mono and diacid (BPD-MA, BPD-DA) enantiomers by Laser-Induced Fluorescence Capillary Electrophoresis has been developed. The limits of detection are 2.06&times;10,M, and the relative standard deviation for the separation was 2.90% to 4.64%. The BPD enantiomers can be quantitatively determined in the range of 10,to 10,mg mL,. In comparison with HPLC, CE has better resolution and efficiency. This separation method was successfully applied to the BPD enantiomers obtained from a matrix of bovine serum and from liposomally formulated material as well as from studies with rat, dog and human microsomes.

New compounds useful in photodynamic therapy are of the formula ##STR1## and their 1,4-diene isomers and the metallated and/or labeled and/or conjugated forms thereof

New compounds expanding the repertoire of compounds useful in photodynamic therapy are described. Monohydrobenzoporphyrins can be obtained in the triacid form or as esters with heteroatom-substituted alcohols, or as amides.

Class of benzoporphyrin derivative photoactive compounds

A group of hydro-monobenzoporphyrins 'green porphyrins' (Gp) having absorption maxima in the range of 670-780 nanometers is useful in treating disorders or conditions which are subject to hematoporphyrin derivative (HPD) treatment in the presence of light, or in treating virus, cells and tissues generally to destroy unwanted targets. The use of the Gp of the invention permits the irradiation for therapy to use wavelengths other than those absorbed by blood. The Gp of the invention may also be conjugated to ligands specific for receptor or to specific immunoglobulins or fragments thereof to target specific tissues or cells for the radiation treatment. Use of these materials permits lower levels of drug to be used, thus preventing side reactions which might destroy normal tissues.

Method of treating skin diseases

Wavelength-specific cytotoxic agents

A group of hydro-monobenzoporphyrins 'green porphyrins' (Gp) having absorption maxima in the range of 670-780 nanometers is useful in treating disorders or conditions which are subject to hematoporphyrin derivative (HPD) treatment in the presence of light, or in treating virus, cells and tissues generally to destroy unwanted targets. The use of the Gp of the invention permits the irradiation to use wavelengths other than those absorbed by blood. The Gp of the invention may also be conjugated to ligands specific for receptor or to specific immunoglobulins or fragments thereof to target specific tissues or cells for the radiation treatment. Use of these materials permits lower levels of drug to be used, thus preventing side reactions which might destroy normal tissues.

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Vancouver, Canada

Ethan D Sternberg