Richter Gedeon Vegyeszeti Gyar Rt

Mta Kozponti Kemiai Kutato Intezete

Eszter Cholnoky

Laszlo Szporny

Elemer Ezer

Eva Palosi

Kalman Harsanyi

Bela Hegedus

Ferenc Trischler

Judit Matuz

Egon Karpati

Gyorgy Hajos

Lilla Forgach

Csaba Kuthi

Katalin Gidai

Marta Kapolnas Nee Pap

Anna Kallay Nee Sohonyai

Gyozo Hortobagyi

Hajnalka Vikar Nee Petho

Lajos Kisfaludy

Helga Tudos Nee Feuer

Laszlo Rogdi

Laszlo Otvos

Hajnalka V Petho

Laszio Szporny

Marta Kapolnas

Anna Kallay

Osaba Kuthi

Sara Ronai Nee Lukacs

Zsuzsanna Tegyey

Csilla Vezert Nee Solyom

The present invention relates to novel optically active or racemic tetrahydro-1,2,4-oxadiazine-5-thione derivatives of the formula ##STR1## methods for their preparation, pharmaceutical compositions comprising the said compounds as active ingredients and a method for the anticonvulsive treatment of mammals, especially human beings. The compounds of the formula I have as good activity as diphenyl hydantoine but their toxicity is much lower.

Novel anticonvulsive tetrahydro-1,2,4-oxadiazine-5-thion derivatives and

The invention relates to new 2-pyridine-thiol derivatives of the formula (I), ##STR1## wherein R is hydrogen or alkyl having from 1 to 4 carbon atoms,

Certain 3- or 4-benzoyl-2-[(2-aminoethyl)thio-pyridines] and their

New intermediate compounds of the formula (I) are disclosed ##STR1## wherein R is hydrogen or C.sub.1 to C.sub.4 alkyl;

2-hydroxy-and 2-halo-ethylthiopyridine intermediates for preparing

The compound N-{2-[(3-benzoyl-1-pyridyl)-thio]-ethyl}-N'-cyano-S-methyl-isothiourea and pharmaceutically acceptable acid addition salts thereof are disclosed as well as pharmaceutical compositions containing same and a method of treatment employing same. The compound or its acid addition salts are effective in treating gastric oedema and thus are useful in ulcer therapy.

N-{2-[(3-benzoyl-2-pyridyl)-thio]-ethyl}-N'-cyano-S-methyl-isothiourea,

Ulcer production in animals is prevented during prolonged antiphlogistic treatment with ulcerogenic quantities of indomethacin by using it in a composition of 1 part of indomethacin to 7.5 to 25 parts, preferably 10 parts by weight of a salicylate. Indomethacin is the most potent ulcerating compound among approved non-steroid antiinflammatory agents.

Treating mammalian subject sensitive to indomethacin ulcerogenisis

Ulcer production in animals is prevented during prolonged antiphlogistic treatment with ulcerogenic quantities of phenylbutazone by using it in a composition of 1 part of antiphlogistic to 0.2 to 50 parts by weight of alkali metal salicylate.

Antiphlogistic composition of phenylbutozone and alkali salicylate and

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Budapest, Hungary

Eszter Cholnoky