Midatech Limited

Esther De Torres Dominguez

Africa Garcia Barrientos

Thomas William Rademacher

Phillip Williams

Christof Bachmann

Javier Del Campo Menoyo

The invention provides a nanoparticle comprising: a core comprising a metal and/or a semiconductor; and a plurality of ligands covalently linked to the core, wherein said ligands comprise: at least one liver-targeting ligand; at least one payload ligand comprising a bioactive agent; and at least one dilution ligand comprising a carbohydrate. Also provided are pharmaceutical compositions comprising the nanoparticles, medical uses thereof, including in the treatment and imaging of liver cancers, and processes for the production of the nanoparticles.

Nanoparticle-based liver-targeting therapy and imaging

Nanoparticles having a core and a corona of ligands covalently linked to the core, wherein peptides are bound to or associated with the nanoparticles.

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Elgoibar, Spain

Esther De Torres Dominguez