Association for the Advancement of Tissue Engineering and Cell Based Technologies & Therapies (a4tec) - Associacão

Association for the Advancement of Tissue Engineer

Estêvão Augusto Rodrigues De Lima

Rui Luis Gonçalves Dos Reis

Ana Rita Cruz Duarte

Carlos André Ribeiro Oliveira

Alexandre António Antunes Barros

Jorge Manuel Nunes Correia Pinto

Rui Luis GONÇALVES Dos Reis

The present disclosure relates to biodegradable ureteral stents comprising an anti-cancer drug, and to a composition for use in medicine that may be used to ensure patency of a channel, namely a mammal ureter, for example, an obstructed ureter by a urinary stone, neoplasia or by a surgical procedure. The biodegradable ureteral stents (BUS) disclosed in the present disclosure unexpectedly allow a proper release of anti-cancer drugs, thus extending the duration of the treatment and increasing the efficacy of the treatment.

Biodegradable ureteral stents, methods and uses thereof

Stents and methods for producing stents are provided. The stent includes a polymeric substrate comprised of 10-50% (w/w) of alginate and 45-85% (w/w) of gelatine and further includes a polymeric biodegradable resin for coating said polymeric substrate. The stent can also include a contrast agent. The stent can further include a crosslinking agent. The method for producing the stent includes dissolving the alginate and gelatine in water and stirring to obtain a polymeric substrate. The method also includes adding a crosslinking agent to the substrate, injecting the substrate into a mold to obtain the stent, placing the stent in a first alcohol solution, and placing the stent in a crosslinking agent solution. The method further includes placing the stent in a second alcohol solution, and a series of interchanging drying and immersing steps.

Ureteral stent, methods and uses thereof

Growing community of inventors

Oporto, Portugal

Estêvão Augusto Rodrigues De Lima