Laboratorios Salvat, S.a.

Ester Monlleó Mas

Juan Lorenzo Catena Ruiz

Isabel Masip Masip

Ángel Messeguer Peypoch

Oscar Rey Puiggros

Albert Antolin Hernandez

Carme Serra Comas

Daniel González Pinacho

Enrique Pérez Payá

Natividad García Villar

Alejandra Moure Fernández

Juanlo Catena Ruiz

Derivatives of 2,5-piperazinedione of formula (I) are apoptotic peptidase activating factor 1 (Apaf-1) inhibitors, therefore they are useful as active pharmaceutical ingredients for the prophylaxis and/or treatment of a pathological and/or physiological condition associated with an increase of apoptosis. 

Apaf-1 inhibitor compounds

The compounds of formula (I) are derived from perhydroquinoline and perhydroisoquinoline and are useful as active pharmaceutical ingredients for the prophylaxis or treatment of diseases caused by 11-beta-hydroxysteroid dehydrogenase type 1 (11-beta-HSD1) enzyme-associated disorders, such as glaucoma, elevated ocular pressure, metabolic disorders, obesity, metabolic syndrome, dyslipidemia, hypertension, diabetes, atherosclerosis, Cushing's syndrome, psoriasis, rheumatoid arthritis, cognitive disorders, Alzheimer's disease or neurodegeneration.

Inhibitor compounds of 11-beta-hydroxysteroid dehydrogenase type 1

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Ester Monlleó Mas