Massachusetts Institute of Technology

Ester Jihae Kwon

Sangeeta N Bhatia

Andrew Warren

Jaideep S Dudani

Leslie W Chan

Aspects of the disclosure relate to methods and compositions useful for in vivo and/or in vitro enzyme profiling. In some embodiments, the disclosure provides methods of in vivo enzymatic processing of exogenous molecules followed by detection of signature molecules as representative of the presence of active enzymes associated with diseases or conditions. In some embodiments, the disclosure provides compositions and in vitro methods for localization of enzymatic activity in a tissue sample.

Methods to spatially profile protease activity in tissue and sections

Disclosed herein are antimicrobial constructs comprising a membrane interacting peptide and an antimicrobial agent. Also disclosed are methods for making and using the constructs.

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Cambridge, MA, United States of America

Ester Jihae Kwon